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Cardiac Myosin Binding Protein-C Phosphorylation Mitigates Age-Related Cardiac Dysfunction: Hope for Better Aging?

Cardiac myosin binding protein-C (cMyBP-C) phosphorylation prevents aging-related cardiac dysfunction. We tested this hypothesis by aging genetic mouse models of hypophosphorylated cMyBP-C, wild-type equivalent, and phosphorylated-mimetic cMyBP-C for 18 to 20 months. Phosphorylated-mimetic cMyBP-C m...

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Detalles Bibliográficos
Autores principales:	Rosas, Paola C., Warren, Chad M., Creed, Heidi A., Trzeciakowski, Jerome P., Solaro, R. John, Tong, Carl W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978553/ https://www.ncbi.nlm.nih.gov/pubmed/31998850 http://dx.doi.org/10.1016/j.jacbts.2019.06.003

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