Differentiation of Pathogenic Th17 Cells Is Negatively Regulated by Let-7 MicroRNAs in a Mouse Model of Multiple Sclerosis

Multiple sclerosis (MS) is a disabling demyelinating autoimmune disorder of the central nervous system (CNS) which is driven by IL-23- and IL-1β-induced autoreactive Th17 cells that traffic to the CNS and secrete proinflammatory cytokines. Th17 pathogenicity in MS has been correlated with the dysreg...

Descripción completa

Detalles Bibliográficos
Autores principales: Angelou, Constance C., Wells, Alexandria C., Vijayaraghavan, Jyothi, Dougan, Carey E., Lawlor, Rebecca, Iverson, Elizabeth, Lazarevic, Vanja, Kimura, Motoko Y., Peyton, Shelly R., Minter, Lisa M., Osborne, Barbara A., Pobezinskaya, Elena L., Pobezinsky, Leonid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978752/
https://www.ncbi.nlm.nih.gov/pubmed/32010153
http://dx.doi.org/10.3389/fimmu.2019.03125

Ejemplares similares

Ejemplares similares