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Beyond Energy Metabolism: Exploiting the Additional Roles of NAMPT for Cancer Therapy
Tumor cells have increased requirements for NAD(+). Thus, many cancers exhibit an increased reliance on NAD(+) production pathways. This dependence may be exploited therapeutically through pharmacological targeting of NAMPT, the rate-limiting enzyme in the NAD(+) salvage pathway. Despite promising p...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978772/ https://www.ncbi.nlm.nih.gov/pubmed/32010616 http://dx.doi.org/10.3389/fonc.2019.01514 |