(18)F-Trifluoromethanesulfinate Enables Direct C–H (18)F-Trifluoromethylation of Native Aromatic Residues in Peptides

[Image: see text] (18)F labeling strategies for unmodified peptides with [(18)F]fluoride require (18)F-labeled prosthetics for bioconjugation more often with cysteine thiols or lysine amines. Here we explore selective radical chemistry to target aromatic residues applying C–H (18)F-trifluoromethylat...

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Detalles Bibliográficos
Autores principales: Kee, Choon Wee, Tack, Osman, Guibbal, Florian, Wilson, Thomas C., Isenegger, Patrick G., Imiołek, Mateusz, Verhoog, Stefan, Tilby, Michael, Boscutti, Giulia, Ashworth, Sharon, Chupin, Juliette, Kashani, Roxana, Poh, Adeline W. J., Sosabowski, Jane K., Macholl, Sven, Plisson, Christophe, Cornelissen, Bart, Willis, Michael C., Passchier, Jan, Davis, Benjamin G., Gouverneur, Véronique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978814/
https://www.ncbi.nlm.nih.gov/pubmed/31913613
http://dx.doi.org/10.1021/jacs.9b11709

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