MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2

Lung cancer is the most common cancer type with increasingly high incidence. MicroRNAs provide the potential biomarkers for lung cancer treatment. Thus, we aimed to investigate the function of microRNA-425-5p in lung cancer development and the underlying mechanisms. MicroRNA-425-5p overexpression in...

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Detalles Bibliográficos
Autores principales: Yu, Xi, Zheng, Hong, Sun, Rongfei, Qian, Xuejiao, Jiang, Ping, Yang, Bo, Liu, Jiangbo, Li, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978817/
https://www.ncbi.nlm.nih.gov/pubmed/31964245
http://dx.doi.org/10.1177/1533033819901115
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author Yu, Xi
Zheng, Hong
Sun, Rongfei
Qian, Xuejiao
Jiang, Ping
Yang, Bo
Liu, Jiangbo
Li, Xiaoping
author_facet Yu, Xi
Zheng, Hong
Sun, Rongfei
Qian, Xuejiao
Jiang, Ping
Yang, Bo
Liu, Jiangbo
Li, Xiaoping
author_sort Yu, Xi
collection PubMed
description Lung cancer is the most common cancer type with increasingly high incidence. MicroRNAs provide the potential biomarkers for lung cancer treatment. Thus, we aimed to investigate the function of microRNA-425-5p in lung cancer development and the underlying mechanisms. MicroRNA-425-5p overexpression inhibited A549 lung cancer cell proliferation in vitro and in vivo. On the other hand, microRNA-425-5p inhibition increased A549 proliferation. Mechanistically, the underlying mechanism by which microRNA-425-5p inhibits lung cancer cell growth was mediated through its ability in targeting and downregulating the TFIIB-related factor 2. Our results for the first time identified microRNA-425-5p as a tumor suppressor in lung cancer. Thus, microRNA-425-5p may serve as a potential therapeutic target for lung cancer.
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spelling pubmed-69788172020-02-06 MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2 Yu, Xi Zheng, Hong Sun, Rongfei Qian, Xuejiao Jiang, Ping Yang, Bo Liu, Jiangbo Li, Xiaoping Technol Cancer Res Treat Original Article Lung cancer is the most common cancer type with increasingly high incidence. MicroRNAs provide the potential biomarkers for lung cancer treatment. Thus, we aimed to investigate the function of microRNA-425-5p in lung cancer development and the underlying mechanisms. MicroRNA-425-5p overexpression inhibited A549 lung cancer cell proliferation in vitro and in vivo. On the other hand, microRNA-425-5p inhibition increased A549 proliferation. Mechanistically, the underlying mechanism by which microRNA-425-5p inhibits lung cancer cell growth was mediated through its ability in targeting and downregulating the TFIIB-related factor 2. Our results for the first time identified microRNA-425-5p as a tumor suppressor in lung cancer. Thus, microRNA-425-5p may serve as a potential therapeutic target for lung cancer. SAGE Publications 2020-01-22 /pmc/articles/PMC6978817/ /pubmed/31964245 http://dx.doi.org/10.1177/1533033819901115 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Yu, Xi
Zheng, Hong
Sun, Rongfei
Qian, Xuejiao
Jiang, Ping
Yang, Bo
Liu, Jiangbo
Li, Xiaoping
MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title_full MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title_fullStr MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title_full_unstemmed MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title_short MicroRNA-425-5p Inhibits Lung Cancer Cell Growth in Vitro and in Vivo by Downregulating TFIIB-Related Factor 2
title_sort microrna-425-5p inhibits lung cancer cell growth in vitro and in vivo by downregulating tfiib-related factor 2
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978817/
https://www.ncbi.nlm.nih.gov/pubmed/31964245
http://dx.doi.org/10.1177/1533033819901115
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