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Programmable Bivalent Peptide–DNA Locks for pH-Based Control of Antibody Activity
[Image: see text] The ability to control antibody activity by pH has important applications in diagnostics, therapeutic antibody targeting, and antibody-guided imaging. Here, we report the rational design of bivalent peptide–DNA ligands that allow pH-dependent control of antibody activity. Our strat...
Autores principales: | Engelen, Wouter, Zhu, Kwankwan, Subedi, Nikita, Idili, Andrea, Ricci, Francesco, Tel, Jurjen, Merkx, Maarten |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2019
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978833/ https://www.ncbi.nlm.nih.gov/pubmed/31989023 http://dx.doi.org/10.1021/acscentsci.9b00964 |
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