Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43

Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H(2)O(2)-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectivel...

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Autores principales: Chen, Ying, Liu, Huazhong, Huang, Hao, Ma, Yuetang, Wang, Ruihua, Hu, Yong, Zheng, Xiufen, Chen, Chunmei, Tang, Hongfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978904/
https://www.ncbi.nlm.nih.gov/pubmed/32009967
http://dx.doi.org/10.3389/fphar.2019.01574
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author Chen, Ying
Liu, Huazhong
Huang, Hao
Ma, Yuetang
Wang, Ruihua
Hu, Yong
Zheng, Xiufen
Chen, Chunmei
Tang, Hongfeng
author_facet Chen, Ying
Liu, Huazhong
Huang, Hao
Ma, Yuetang
Wang, Ruihua
Hu, Yong
Zheng, Xiufen
Chen, Chunmei
Tang, Hongfeng
author_sort Chen, Ying
collection PubMed
description Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H(2)O(2)-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectively reduce the fibroblast oxidative damage mediated by the up-regulation of NADPH oxidase and Connexin43. Concurrently, squid ink polysaccharides decrease the ROS induced up-regulation of MMP1 and MMP9 to decrease MMP-mediated skin aging. Therefore, we hypothesize that squid ink polysaccharides play an antioxidant role by inhibiting the expression of NADPH oxidase and connexin43. This provides a new target for the effective clinical prevention and treatment of oxidative skin damage.
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spelling pubmed-69789042020-02-01 Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43 Chen, Ying Liu, Huazhong Huang, Hao Ma, Yuetang Wang, Ruihua Hu, Yong Zheng, Xiufen Chen, Chunmei Tang, Hongfeng Front Pharmacol Pharmacology Oxidation injury to skin is one of the main reasons for skin aging. The aim of the present study was to explore the protective effect of squid ink polysaccharides and its mechanism of action against H(2)O(2)-induced dermal fibroblast damage. Our results show that squid ink polysaccharides effectively reduce the fibroblast oxidative damage mediated by the up-regulation of NADPH oxidase and Connexin43. Concurrently, squid ink polysaccharides decrease the ROS induced up-regulation of MMP1 and MMP9 to decrease MMP-mediated skin aging. Therefore, we hypothesize that squid ink polysaccharides play an antioxidant role by inhibiting the expression of NADPH oxidase and connexin43. This provides a new target for the effective clinical prevention and treatment of oxidative skin damage. Frontiers Media S.A. 2020-01-17 /pmc/articles/PMC6978904/ /pubmed/32009967 http://dx.doi.org/10.3389/fphar.2019.01574 Text en Copyright © 2020 Chen, Liu, Huang, Ma, Wang, Hu, Zheng, Chen and Tang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Chen, Ying
Liu, Huazhong
Huang, Hao
Ma, Yuetang
Wang, Ruihua
Hu, Yong
Zheng, Xiufen
Chen, Chunmei
Tang, Hongfeng
Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title_full Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title_fullStr Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title_full_unstemmed Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title_short Squid Ink Polysaccharides Protect Human Fibroblast Against Oxidative Stress by Regulating NADPH Oxidase and Connexin43
title_sort squid ink polysaccharides protect human fibroblast against oxidative stress by regulating nadph oxidase and connexin43
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978904/
https://www.ncbi.nlm.nih.gov/pubmed/32009967
http://dx.doi.org/10.3389/fphar.2019.01574
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