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Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies
Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it.
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978909/ https://www.ncbi.nlm.nih.gov/pubmed/32010137 http://dx.doi.org/10.3389/fimmu.2019.03078 |
| _version_ | 1783490795791187968 |
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| author | Scott, David W. Pratt, Kathleen P. |
| author_facet | Scott, David W. Pratt, Kathleen P. |
| author_sort | Scott, David W. |
| collection | PubMed |
| description | Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it. |
| format | Online Article Text |
| id | pubmed-6978909 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Frontiers Media S.A. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69789092020-02-01 Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies Scott, David W. Pratt, Kathleen P. Front Immunol Immunology Therapeutic treatment of bleeds with FVIII can lead to an antibody response that effectively inhibits its function. Herein, we review the factors that contribute to this immunogenicity and possible ways to overcome it. Frontiers Media S.A. 2020-01-17 /pmc/articles/PMC6978909/ /pubmed/32010137 http://dx.doi.org/10.3389/fimmu.2019.03078 Text en Copyright © 2020 Scott and Pratt. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| spellingShingle | Immunology Scott, David W. Pratt, Kathleen P. Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title | Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title_full | Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title_fullStr | Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title_full_unstemmed | Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title_short | Factor VIII: Perspectives on Immunogenicity and Tolerogenic Strategies |
| title_sort | factor viii: perspectives on immunogenicity and tolerogenic strategies |
| topic | Immunology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978909/ https://www.ncbi.nlm.nih.gov/pubmed/32010137 http://dx.doi.org/10.3389/fimmu.2019.03078 |
| work_keys_str_mv | AT scottdavidw factorviiiperspectivesonimmunogenicityandtolerogenicstrategies AT prattkathleenp factorviiiperspectivesonimmunogenicityandtolerogenicstrategies |