Cargando…

Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy

Background: Major Depressive Disorder (MDD) is highly prevalent in patients with mesial temporal lobe epilepsy (MTLE), especially in women, carrying significant morbidity. This study aimed to investigate the cortical thickness (CT) abnormalities associated with MDD in women with MTLE and hippocampal...

Descripción completa

Detalles Bibliográficos
Autores principales: Nogueira, Mateus Henrique, Pimentel da Silva, Luciana Ramalho, Vasques Moreira, José Carlos, de Rezende, Thiago Junqueira Ribeiro, Zanão, Tamires Araújo, de Campos, Brunno Machado, Yasuda, Clarissa Lin, Cendes, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979005/
https://www.ncbi.nlm.nih.gov/pubmed/32010051
http://dx.doi.org/10.3389/fneur.2019.01398
_version_ 1783490812728836096
author Nogueira, Mateus Henrique
Pimentel da Silva, Luciana Ramalho
Vasques Moreira, José Carlos
de Rezende, Thiago Junqueira Ribeiro
Zanão, Tamires Araújo
de Campos, Brunno Machado
Yasuda, Clarissa Lin
Cendes, Fernando
author_facet Nogueira, Mateus Henrique
Pimentel da Silva, Luciana Ramalho
Vasques Moreira, José Carlos
de Rezende, Thiago Junqueira Ribeiro
Zanão, Tamires Araújo
de Campos, Brunno Machado
Yasuda, Clarissa Lin
Cendes, Fernando
author_sort Nogueira, Mateus Henrique
collection PubMed
description Background: Major Depressive Disorder (MDD) is highly prevalent in patients with mesial temporal lobe epilepsy (MTLE), especially in women, carrying significant morbidity. This study aimed to investigate the cortical thickness (CT) abnormalities associated with MDD in women with MTLE and hippocampal atrophy (HA). Also, we investigated the impact of MDD upon the volumes of the hippocampus and amygdala in these patients. Methods: We included 50 women with MTLE and HA (20 left, LMTLE; 30 right, RMTLE), 41 healthy women in the control group, and 15 women with MDD without epilepsy. MTLE patients were subdivided into three groups: MTLE-without-MDD (23 MTLE patients without MDD), MTLE-mild-MDD (nine MTLE patients with mild symptoms of MDD), and MTLE-severe-MDD (18 MTLE patients with moderate to severe symptoms of MDD). The five groups were balanced for age (p = 0.56). All participants had high-resolution 3D T1-weighted images in a 3T scanner. We used FreeSurfer 6.0 for volumetry and CT parcellation. All participants were submitted to a clinical psychological evaluation through the Structured Clinical Interview for DSM-IV (SCID-IV) and completed the Beck Depression Inventory (BDI-II). Results: We identified a smaller ipsilateral amygdala volume (p = 0.04) in the MTLE-severe-MDD group when compared to the control group. Our results presented a reduced ipsilateral lateral orbitofrontal cortex (p = 0.02) in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. We also identified a thinner ipsilateral fusiform gyrus (p < 0.01) in the MTLE-severe-MDD compared to both MTLE-without-MDD and control groups. A reduced CT of the contralateral superior frontal gyrus (p = 0.02) was observed in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. Conclusions: The identification of areas with reduced CT and atrophy of the ipsilateral amygdala in women with MTLE and MDD suggest that the cortical thinning in the network of the paralimbic system is related to the co-occurrence and intensity of depressive symptoms in this group.
format Online
Article
Text
id pubmed-6979005
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-69790052020-02-01 Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy Nogueira, Mateus Henrique Pimentel da Silva, Luciana Ramalho Vasques Moreira, José Carlos de Rezende, Thiago Junqueira Ribeiro Zanão, Tamires Araújo de Campos, Brunno Machado Yasuda, Clarissa Lin Cendes, Fernando Front Neurol Neurology Background: Major Depressive Disorder (MDD) is highly prevalent in patients with mesial temporal lobe epilepsy (MTLE), especially in women, carrying significant morbidity. This study aimed to investigate the cortical thickness (CT) abnormalities associated with MDD in women with MTLE and hippocampal atrophy (HA). Also, we investigated the impact of MDD upon the volumes of the hippocampus and amygdala in these patients. Methods: We included 50 women with MTLE and HA (20 left, LMTLE; 30 right, RMTLE), 41 healthy women in the control group, and 15 women with MDD without epilepsy. MTLE patients were subdivided into three groups: MTLE-without-MDD (23 MTLE patients without MDD), MTLE-mild-MDD (nine MTLE patients with mild symptoms of MDD), and MTLE-severe-MDD (18 MTLE patients with moderate to severe symptoms of MDD). The five groups were balanced for age (p = 0.56). All participants had high-resolution 3D T1-weighted images in a 3T scanner. We used FreeSurfer 6.0 for volumetry and CT parcellation. All participants were submitted to a clinical psychological evaluation through the Structured Clinical Interview for DSM-IV (SCID-IV) and completed the Beck Depression Inventory (BDI-II). Results: We identified a smaller ipsilateral amygdala volume (p = 0.04) in the MTLE-severe-MDD group when compared to the control group. Our results presented a reduced ipsilateral lateral orbitofrontal cortex (p = 0.02) in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. We also identified a thinner ipsilateral fusiform gyrus (p < 0.01) in the MTLE-severe-MDD compared to both MTLE-without-MDD and control groups. A reduced CT of the contralateral superior frontal gyrus (p = 0.02) was observed in the MTLE-severe-MDD in comparison to the MTLE-mild-MDD group. Conclusions: The identification of areas with reduced CT and atrophy of the ipsilateral amygdala in women with MTLE and MDD suggest that the cortical thinning in the network of the paralimbic system is related to the co-occurrence and intensity of depressive symptoms in this group. Frontiers Media S.A. 2020-01-17 /pmc/articles/PMC6979005/ /pubmed/32010051 http://dx.doi.org/10.3389/fneur.2019.01398 Text en Copyright © 2020 Nogueira, Pimentel da Silva, Vasques Moreira, Rezende, Zanão, Campos, Yasuda and Cendes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Nogueira, Mateus Henrique
Pimentel da Silva, Luciana Ramalho
Vasques Moreira, José Carlos
de Rezende, Thiago Junqueira Ribeiro
Zanão, Tamires Araújo
de Campos, Brunno Machado
Yasuda, Clarissa Lin
Cendes, Fernando
Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title_full Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title_fullStr Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title_full_unstemmed Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title_short Major Depressive Disorder Associated With Reduced Cortical Thickness in Women With Temporal Lobe Epilepsy
title_sort major depressive disorder associated with reduced cortical thickness in women with temporal lobe epilepsy
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979005/
https://www.ncbi.nlm.nih.gov/pubmed/32010051
http://dx.doi.org/10.3389/fneur.2019.01398
work_keys_str_mv AT nogueiramateushenrique majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT pimenteldasilvalucianaramalho majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT vasquesmoreirajosecarlos majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT derezendethiagojunqueiraribeiro majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT zanaotamiresaraujo majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT decamposbrunnomachado majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT yasudaclarissalin majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy
AT cendesfernando majordepressivedisorderassociatedwithreducedcorticalthicknessinwomenwithtemporallobeepilepsy