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Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil

BACKGROUND: Pulmonary hypertension (PH) can develop secondary to many common cardiopulmonary diseases, and the use of sildenafil has improved care of affected dogs. OBJECTIVE: To evaluate response to sildenafil in dogs with respiratory‐associated PH. ANIMALS: Twenty‐five dogs with PH. METHODS: Prosp...

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Autores principales: Johnson, Lynelle R., Stern, Joshua A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979098/
https://www.ncbi.nlm.nih.gov/pubmed/31816127
http://dx.doi.org/10.1111/jvim.15679
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author Johnson, Lynelle R.
Stern, Joshua A.
author_facet Johnson, Lynelle R.
Stern, Joshua A.
author_sort Johnson, Lynelle R.
collection PubMed
description BACKGROUND: Pulmonary hypertension (PH) can develop secondary to many common cardiopulmonary diseases, and the use of sildenafil has improved care of affected dogs. OBJECTIVE: To evaluate response to sildenafil in dogs with respiratory‐associated PH. ANIMALS: Twenty‐five dogs with PH. METHODS: Prospective clinical trial. Doppler echocardiography identified dogs with moderate to severe PH, and additional tests were performed to detect underlying diseases. A 17‐point quality of life (QOL) questionnaire was completed, and sildenafil was prescribed, along with other medications deemed necessary for the management of clinically diagnosed respiratory diseases. After 30 days, dogs returned to the hospital for repeat echocardiogram and QOL survey. RESULTS: The median age was 12.4 years, and most dogs were small breed dogs (median weight, 6.5 kg). Syncope (64%), cough (56%), and respiratory difficulty (32%) were the most common presenting complaints. Respiratory diseases associated with PH included tracheobronchomalacia, pulmonary fibrosis, inflammatory airway disease, and brachycephalic syndrome, with multiple diseases in some dogs. Eight of 25 dogs (32%) died or were euthanized within 1 month. In the remaining dogs, tricuspid regurgitation pressure gradient (83.0 ± 17.4 mm Hg before, 55.4 ± 17.4 mm Hg after) and QOL scores were significantly improved after 1 month of sildenafil. Fifty percent mortality was reached 6 months after study entry, with 4 dogs alive 5 years after diagnosis. CONCLUSIONS AND CLINICAL IMPORTANCE: Sildenafil responsiveness is variable in dogs with respiratory‐associated PH, but improved QOL was demonstrated in dogs surviving >1 month, and long‐term survival was noted in some cases.
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spelling pubmed-69790982020-01-28 Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil Johnson, Lynelle R. Stern, Joshua A. J Vet Intern Med SMALL ANIMAL BACKGROUND: Pulmonary hypertension (PH) can develop secondary to many common cardiopulmonary diseases, and the use of sildenafil has improved care of affected dogs. OBJECTIVE: To evaluate response to sildenafil in dogs with respiratory‐associated PH. ANIMALS: Twenty‐five dogs with PH. METHODS: Prospective clinical trial. Doppler echocardiography identified dogs with moderate to severe PH, and additional tests were performed to detect underlying diseases. A 17‐point quality of life (QOL) questionnaire was completed, and sildenafil was prescribed, along with other medications deemed necessary for the management of clinically diagnosed respiratory diseases. After 30 days, dogs returned to the hospital for repeat echocardiogram and QOL survey. RESULTS: The median age was 12.4 years, and most dogs were small breed dogs (median weight, 6.5 kg). Syncope (64%), cough (56%), and respiratory difficulty (32%) were the most common presenting complaints. Respiratory diseases associated with PH included tracheobronchomalacia, pulmonary fibrosis, inflammatory airway disease, and brachycephalic syndrome, with multiple diseases in some dogs. Eight of 25 dogs (32%) died or were euthanized within 1 month. In the remaining dogs, tricuspid regurgitation pressure gradient (83.0 ± 17.4 mm Hg before, 55.4 ± 17.4 mm Hg after) and QOL scores were significantly improved after 1 month of sildenafil. Fifty percent mortality was reached 6 months after study entry, with 4 dogs alive 5 years after diagnosis. CONCLUSIONS AND CLINICAL IMPORTANCE: Sildenafil responsiveness is variable in dogs with respiratory‐associated PH, but improved QOL was demonstrated in dogs surviving >1 month, and long‐term survival was noted in some cases. John Wiley & Sons, Inc. 2019-12-09 2020 /pmc/articles/PMC6979098/ /pubmed/31816127 http://dx.doi.org/10.1111/jvim.15679 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle SMALL ANIMAL
Johnson, Lynelle R.
Stern, Joshua A.
Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title_full Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title_fullStr Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title_full_unstemmed Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title_short Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
title_sort clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil
topic SMALL ANIMAL
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979098/
https://www.ncbi.nlm.nih.gov/pubmed/31816127
http://dx.doi.org/10.1111/jvim.15679
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