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Network Models Predict That Pyramidal Neuron Hyperexcitability and Synapse Loss in the dlPFC Lead to Age-Related Spatial Working Memory Impairment in Rhesus Monkeys
Behavioral studies have shown spatial working memory impairment with aging in several animal species, including humans. Persistent activity of layer 3 pyramidal dorsolateral prefrontal cortex (dlPFC) neurons during delay periods of working memory tasks is important for encoding memory of the stimulu...
Autores principales: | Ibañez, Sara, Luebke, Jennifer I., Chang, Wayne, Draguljić, Danel, Weaver, Christina M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979278/ https://www.ncbi.nlm.nih.gov/pubmed/32009920 http://dx.doi.org/10.3389/fncom.2019.00089 |
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