Cancer-associated fibroblasts promote prostate tumor growth and progression through upregulation of cholesterol and steroid biosynthesis

BACKGROUND: Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clinical management of patients, also because the molecular mechanisms behind thera...

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Detalles Bibliográficos
Autores principales: Neuwirt, Hannes, Bouchal, Jan, Kharaishvili, Gvantsa, Ploner, Christian, Jöhrer, Karin, Pitterl, Florian, Weber, Anja, Klocker, Helmut, Eder, Iris E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979368/
https://www.ncbi.nlm.nih.gov/pubmed/31980029
http://dx.doi.org/10.1186/s12964-019-0505-5

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