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MCT4 regulates de novo pyrimidine biosynthesis in GBM in a lactate-independent manner

BACKGROUND: Necrotic foci with surrounding hypoxic cellular pseudopalisades and microvascular hyperplasia are histological features found in glioblastoma (GBM). We have previously shown that monocarboxylate transporter 4 (MCT4) is highly expressed in necrotic/hypoxic regions in GBM and that increase...

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Detalles Bibliográficos
Autores principales:	Spina, Raffaella, Voss, Dillon M, Yang, Xiaohua, Sohn, Jason W, Vinkler, Robert, Schraner, Julianna, Sloan, Anthony, Welford, Scott M, Avril, Norbert, Ames, Heather M, Woodworth, Graeme F, Bar, Eli E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979491/ https://www.ncbi.nlm.nih.gov/pubmed/32002519 http://dx.doi.org/10.1093/noajnl/vdz062

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