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Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2

BACKGROUND: The molecular changes involved in Alzheimer’s disease (AD) progression remain unclear since we cannot easily access antemortem human brains. Some non-mammalian vertebrates such as the zebrafish preserve AD-relevant transcript isoforms of the PRESENILIN genes lost from mice and rats. One...

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Detalles Bibliográficos
Autores principales:	Hin, Nhi, Newman, Morgan, Kaslin, Jan, Douek, Alon M., Lumsden, Amanda, Nik, Seyed Hani Moussavi, Dong, Yang, Zhou, Xin-Fu, Mañucat-Tan, Noralyn B., Ludington, Alastair, Adelson, David L., Pederson, Stephen, Lardelli, Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980398/ https://www.ncbi.nlm.nih.gov/pubmed/31978074 http://dx.doi.org/10.1371/journal.pone.0227258

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