Yap suppresses T-cell function and infiltration in the tumor microenvironment

A major challenge for cancer immunotherapy is sustaining T-cell activation and recruitment in immunosuppressive solid tumors. Here, we report that the levels of the Hippo pathway effector Yes-associated protein (Yap) are sharply induced upon the activation of cluster of differentiation 4 (CD4)-posit...

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Detalles Bibliográficos
Autores principales: Stampouloglou, Eleni, Cheng, Nan, Federico, Anthony, Slaby, Emily, Monti, Stefano, Szeto, Gregory L., Varelas, Xaralabos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980695/
https://www.ncbi.nlm.nih.gov/pubmed/31929526
http://dx.doi.org/10.1371/journal.pbio.3000591

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