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Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous train...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980817/ https://www.ncbi.nlm.nih.gov/pubmed/32002053 http://dx.doi.org/10.3889/oamjms.2019.425 |
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author | Machrina, Yetty Purba, Ambrosius Lindarto, Dharma Maskoen, Ani Melani |
author_facet | Machrina, Yetty Purba, Ambrosius Lindarto, Dharma Maskoen, Ani Melani |
author_sort | Machrina, Yetty |
collection | PubMed |
description | AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous training, and severe continuous training. Treated groups were assigned to run on the treadmill three times a week for eight weeks consequently. RESULTS: The result shown that expression of mRNA IR gene in treated groups decline compared to control. There was a difference mRNA IR gene expression after eight weeks of exercise between MCT and control, SCT and control so are MCT and SCT. IR expression on skeletal muscle in treated groups was different compared with control. The distribution of IR on skeletal muscles in treatment groups was significantly increased compared control, but there was no significant difference distribution between MCT and SCT. HOMA-IR post-test in SCT was lower than MCT but FBG post-test lower in MCT than SCT. CONCLUSION: The intensity of exercise makes a difference in IR gene expression between moderate continuous training and severe continuous training after eight weeks of assigned exercise in T2DM rat models. |
format | Online Article Text |
id | pubmed-6980817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-69808172020-01-30 Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model Machrina, Yetty Purba, Ambrosius Lindarto, Dharma Maskoen, Ani Melani Open Access Maced J Med Sci Tropical and Infectious Diseases Control and Management AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous training, and severe continuous training. Treated groups were assigned to run on the treadmill three times a week for eight weeks consequently. RESULTS: The result shown that expression of mRNA IR gene in treated groups decline compared to control. There was a difference mRNA IR gene expression after eight weeks of exercise between MCT and control, SCT and control so are MCT and SCT. IR expression on skeletal muscle in treated groups was different compared with control. The distribution of IR on skeletal muscles in treatment groups was significantly increased compared control, but there was no significant difference distribution between MCT and SCT. HOMA-IR post-test in SCT was lower than MCT but FBG post-test lower in MCT than SCT. CONCLUSION: The intensity of exercise makes a difference in IR gene expression between moderate continuous training and severe continuous training after eight weeks of assigned exercise in T2DM rat models. Republic of Macedonia 2019-10-14 /pmc/articles/PMC6980817/ /pubmed/32002053 http://dx.doi.org/10.3889/oamjms.2019.425 Text en Copyright: © 2019 Yetty Machrina, Ambrosius Purba, Dharma Lindarto, Ani Melani Maskoen. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) |
spellingShingle | Tropical and Infectious Diseases Control and Management Machrina, Yetty Purba, Ambrosius Lindarto, Dharma Maskoen, Ani Melani Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title | Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title_full | Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title_fullStr | Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title_full_unstemmed | Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title_short | Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model |
title_sort | exercise intensity alter insulin receptor gene expression in diabetic type - 2 rat model |
topic | Tropical and Infectious Diseases Control and Management |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980817/ https://www.ncbi.nlm.nih.gov/pubmed/32002053 http://dx.doi.org/10.3889/oamjms.2019.425 |
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