Cargando…

Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model

AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous train...

Descripción completa

Detalles Bibliográficos
Autores principales: Machrina, Yetty, Purba, Ambrosius, Lindarto, Dharma, Maskoen, Ani Melani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Republic of Macedonia 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980817/
https://www.ncbi.nlm.nih.gov/pubmed/32002053
http://dx.doi.org/10.3889/oamjms.2019.425
_version_ 1783490996071301120
author Machrina, Yetty
Purba, Ambrosius
Lindarto, Dharma
Maskoen, Ani Melani
author_facet Machrina, Yetty
Purba, Ambrosius
Lindarto, Dharma
Maskoen, Ani Melani
author_sort Machrina, Yetty
collection PubMed
description AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous training, and severe continuous training. Treated groups were assigned to run on the treadmill three times a week for eight weeks consequently. RESULTS: The result shown that expression of mRNA IR gene in treated groups decline compared to control. There was a difference mRNA IR gene expression after eight weeks of exercise between MCT and control, SCT and control so are MCT and SCT. IR expression on skeletal muscle in treated groups was different compared with control. The distribution of IR on skeletal muscles in treatment groups was significantly increased compared control, but there was no significant difference distribution between MCT and SCT. HOMA-IR post-test in SCT was lower than MCT but FBG post-test lower in MCT than SCT. CONCLUSION: The intensity of exercise makes a difference in IR gene expression between moderate continuous training and severe continuous training after eight weeks of assigned exercise in T2DM rat models.
format Online
Article
Text
id pubmed-6980817
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Republic of Macedonia
record_format MEDLINE/PubMed
spelling pubmed-69808172020-01-30 Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model Machrina, Yetty Purba, Ambrosius Lindarto, Dharma Maskoen, Ani Melani Open Access Maced J Med Sci Tropical and Infectious Diseases Control and Management AIM: To analyse the differential expression of the insulin receptor (IR) gene between moderate continuous and severe continuous training in the T2DM rat model. METHODS: This was an experimental study. Healthy male Wistar was used in this study, which divided into sedentary, moderate continuous training, and severe continuous training. Treated groups were assigned to run on the treadmill three times a week for eight weeks consequently. RESULTS: The result shown that expression of mRNA IR gene in treated groups decline compared to control. There was a difference mRNA IR gene expression after eight weeks of exercise between MCT and control, SCT and control so are MCT and SCT. IR expression on skeletal muscle in treated groups was different compared with control. The distribution of IR on skeletal muscles in treatment groups was significantly increased compared control, but there was no significant difference distribution between MCT and SCT. HOMA-IR post-test in SCT was lower than MCT but FBG post-test lower in MCT than SCT. CONCLUSION: The intensity of exercise makes a difference in IR gene expression between moderate continuous training and severe continuous training after eight weeks of assigned exercise in T2DM rat models. Republic of Macedonia 2019-10-14 /pmc/articles/PMC6980817/ /pubmed/32002053 http://dx.doi.org/10.3889/oamjms.2019.425 Text en Copyright: © 2019 Yetty Machrina, Ambrosius Purba, Dharma Lindarto, Ani Melani Maskoen. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0)
spellingShingle Tropical and Infectious Diseases Control and Management
Machrina, Yetty
Purba, Ambrosius
Lindarto, Dharma
Maskoen, Ani Melani
Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title_full Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title_fullStr Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title_full_unstemmed Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title_short Exercise Intensity Alter Insulin Receptor Gene Expression in Diabetic Type - 2 Rat Model
title_sort exercise intensity alter insulin receptor gene expression in diabetic type - 2 rat model
topic Tropical and Infectious Diseases Control and Management
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980817/
https://www.ncbi.nlm.nih.gov/pubmed/32002053
http://dx.doi.org/10.3889/oamjms.2019.425
work_keys_str_mv AT machrinayetty exerciseintensityalterinsulinreceptorgeneexpressionindiabetictype2ratmodel
AT purbaambrosius exerciseintensityalterinsulinreceptorgeneexpressionindiabetictype2ratmodel
AT lindartodharma exerciseintensityalterinsulinreceptorgeneexpressionindiabetictype2ratmodel
AT maskoenanimelani exerciseintensityalterinsulinreceptorgeneexpressionindiabetictype2ratmodel