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Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice
BACKGROUND: The prevalence of cardiovascular disease (CVD) and its mortality continues to increase. Various studies have shown aspirin can reduce CVD mortality but has adverse side effects. Research on a comparison between aspirin and honey has not been done, but both have antiplatelet effects. AIM:...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Republic of Macedonia
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980826/ https://www.ncbi.nlm.nih.gov/pubmed/32002064 http://dx.doi.org/10.3889/oamjms.2019.431 |
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author | Martina, Sake Juli Ramar, Logaselvi A. P. Silaban, Michael R. I. Luthfi, Muhammad Govindan, Pradeepa A. P. |
author_facet | Martina, Sake Juli Ramar, Logaselvi A. P. Silaban, Michael R. I. Luthfi, Muhammad Govindan, Pradeepa A. P. |
author_sort | Martina, Sake Juli |
collection | PubMed |
description | BACKGROUND: The prevalence of cardiovascular disease (CVD) and its mortality continues to increase. Various studies have shown aspirin can reduce CVD mortality but has adverse side effects. Research on a comparison between aspirin and honey has not been done, but both have antiplatelet effects. AIM: This study is aimed to prove the antiplatelet effects on honey and compare the antiplatelet effects of aspirin with honey based on the bleeding time in mice. METHODS: This study is a true experimental design with a post-test only control group using 32 male mice, Double Ditsch Webster, ± 3 months old, the weight of 20-30 g, divided into 4 groups. Consisting of a negative control group (placebo), aspirin and honey. The suspension has given orally for 12 days using the probe. The research was conducted at the Laboratory of Pharmacology Department of Pharmacology and Therapeutics Faculty of Medicine, the University of North Sumatra in September until December 2015. The data collected was bleeding time in mice. Data analysed by Shapiro Wilk test, Kruskal Wallis and Mann Whitney. RESULTS: The mean bleeding time was a placebo (102.88 seconds), aspirin (369.38 seconds) and honey (304.63 seconds). Mann Whitney test showed significant results in the aspirin and honey groups against the control group (placebo) with p = 0.001. There were no significant differences in the aspirin group against honey (p = 0.172). Honey has an antiplatelet effect in mice. The mean bleeding time in mice given honey is longer or closer to the mean bleeding time in the aspirin group. CONCLUSION: The results could be used as a basis for further research to determine its use in humans with cardiovascular disease. |
format | Online Article Text |
id | pubmed-6980826 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Republic of Macedonia |
record_format | MEDLINE/PubMed |
spelling | pubmed-69808262020-01-30 Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice Martina, Sake Juli Ramar, Logaselvi A. P. Silaban, Michael R. I. Luthfi, Muhammad Govindan, Pradeepa A. P. Open Access Maced J Med Sci Tropical and Infectious Diseases Control and Management BACKGROUND: The prevalence of cardiovascular disease (CVD) and its mortality continues to increase. Various studies have shown aspirin can reduce CVD mortality but has adverse side effects. Research on a comparison between aspirin and honey has not been done, but both have antiplatelet effects. AIM: This study is aimed to prove the antiplatelet effects on honey and compare the antiplatelet effects of aspirin with honey based on the bleeding time in mice. METHODS: This study is a true experimental design with a post-test only control group using 32 male mice, Double Ditsch Webster, ± 3 months old, the weight of 20-30 g, divided into 4 groups. Consisting of a negative control group (placebo), aspirin and honey. The suspension has given orally for 12 days using the probe. The research was conducted at the Laboratory of Pharmacology Department of Pharmacology and Therapeutics Faculty of Medicine, the University of North Sumatra in September until December 2015. The data collected was bleeding time in mice. Data analysed by Shapiro Wilk test, Kruskal Wallis and Mann Whitney. RESULTS: The mean bleeding time was a placebo (102.88 seconds), aspirin (369.38 seconds) and honey (304.63 seconds). Mann Whitney test showed significant results in the aspirin and honey groups against the control group (placebo) with p = 0.001. There were no significant differences in the aspirin group against honey (p = 0.172). Honey has an antiplatelet effect in mice. The mean bleeding time in mice given honey is longer or closer to the mean bleeding time in the aspirin group. CONCLUSION: The results could be used as a basis for further research to determine its use in humans with cardiovascular disease. Republic of Macedonia 2019-10-14 /pmc/articles/PMC6980826/ /pubmed/32002064 http://dx.doi.org/10.3889/oamjms.2019.431 Text en Copyright: © 2019 Sake Juli Martina, Logaselvi A.P. Ramar, Michael R.I. Silaban, Muhammad Luthfi, Pradeepa A.P. Govindan. http://creativecommons.org/licenses/CC BY-NC/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0) |
spellingShingle | Tropical and Infectious Diseases Control and Management Martina, Sake Juli Ramar, Logaselvi A. P. Silaban, Michael R. I. Luthfi, Muhammad Govindan, Pradeepa A. P. Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title | Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title_full | Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title_fullStr | Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title_full_unstemmed | Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title_short | Antiplatelet Effectivity between Aspirin with Honey on Cardiovascular Disease Based on Bleeding Time Taken on Mice |
title_sort | antiplatelet effectivity between aspirin with honey on cardiovascular disease based on bleeding time taken on mice |
topic | Tropical and Infectious Diseases Control and Management |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980826/ https://www.ncbi.nlm.nih.gov/pubmed/32002064 http://dx.doi.org/10.3889/oamjms.2019.431 |
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