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Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density

PURPOSE: To compare the effect of three different phakic intraocular lenses (pIOLs) on the corneal endothelial cell density (ECD). PATIENTS AND METHODS: This was a prospective observational cohort study that included 60 eyes (30 patients) with axial myopia of −6.50 to −22.00 diopters (D). The Verisy...

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Autores principales: Shaaban, Yasmine Maher, Badran, Tamer Abdel Fattah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980859/
https://www.ncbi.nlm.nih.gov/pubmed/32021080
http://dx.doi.org/10.2147/OPTH.S236041
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author Shaaban, Yasmine Maher
Badran, Tamer Abdel Fattah
author_facet Shaaban, Yasmine Maher
Badran, Tamer Abdel Fattah
author_sort Shaaban, Yasmine Maher
collection PubMed
description PURPOSE: To compare the effect of three different phakic intraocular lenses (pIOLs) on the corneal endothelial cell density (ECD). PATIENTS AND METHODS: This was a prospective observational cohort study that included 60 eyes (30 patients) with axial myopia of −6.50 to −22.00 diopters (D). The Verisyse anterior chamber (AC) rigid iris fixated pIOL, the Veriflex (AC) flexible iris fixated pIOL, and the Visian posterior chamber (PC) implantable collamer lens (ICL) were implanted in three equal groups of patients. The effect of the three pIOLs on the ECD was compared over a follow-up period of one week, and one, three, and six months, and one, two, and three years. Specular microscopy was done to evaluate the cornea before the surgery and throughout the study. Changes were statistically analyzed and compared. RESULTS: In the first three postoperative months, Verisyse and Veriflex pIOLs induced almost the same amount of endothelial cells loss of 10.3% and 10.6%, respectively, while ICLs showed endothelial cells loss of 3.5%. At the end of the three-year study, Veriflex pIOLs induced the highest rate of endothelial cell loss of 25%, while Verisyse and ICL lenses showed endothelial cells loss of 15.7% and 13.4%, respectively. The main effect of time and type of lens was statistically significant (p<0.001). CONCLUSION: All pIOLs cause a decrease in ECD. The AC pIOLs tend to be associated with more cell loss than PC pIOLs. Surgical insult is the important factor responsible for the early endothelial cell loss, while the material from which the pIOL is made may be an important factor for the continuous corneal endothelial cell loss over a long time.
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spelling pubmed-69808592020-02-04 Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density Shaaban, Yasmine Maher Badran, Tamer Abdel Fattah Clin Ophthalmol Original Research PURPOSE: To compare the effect of three different phakic intraocular lenses (pIOLs) on the corneal endothelial cell density (ECD). PATIENTS AND METHODS: This was a prospective observational cohort study that included 60 eyes (30 patients) with axial myopia of −6.50 to −22.00 diopters (D). The Verisyse anterior chamber (AC) rigid iris fixated pIOL, the Veriflex (AC) flexible iris fixated pIOL, and the Visian posterior chamber (PC) implantable collamer lens (ICL) were implanted in three equal groups of patients. The effect of the three pIOLs on the ECD was compared over a follow-up period of one week, and one, three, and six months, and one, two, and three years. Specular microscopy was done to evaluate the cornea before the surgery and throughout the study. Changes were statistically analyzed and compared. RESULTS: In the first three postoperative months, Verisyse and Veriflex pIOLs induced almost the same amount of endothelial cells loss of 10.3% and 10.6%, respectively, while ICLs showed endothelial cells loss of 3.5%. At the end of the three-year study, Veriflex pIOLs induced the highest rate of endothelial cell loss of 25%, while Verisyse and ICL lenses showed endothelial cells loss of 15.7% and 13.4%, respectively. The main effect of time and type of lens was statistically significant (p<0.001). CONCLUSION: All pIOLs cause a decrease in ECD. The AC pIOLs tend to be associated with more cell loss than PC pIOLs. Surgical insult is the important factor responsible for the early endothelial cell loss, while the material from which the pIOL is made may be an important factor for the continuous corneal endothelial cell loss over a long time. Dove 2020-01-20 /pmc/articles/PMC6980859/ /pubmed/32021080 http://dx.doi.org/10.2147/OPTH.S236041 Text en © 2020 Shaaban and Badran. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Shaaban, Yasmine Maher
Badran, Tamer Abdel Fattah
Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title_full Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title_fullStr Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title_full_unstemmed Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title_short Three-Year Effect of Phakic Intraocular Lenses on the Corneal Endothelial Cell Density
title_sort three-year effect of phakic intraocular lenses on the corneal endothelial cell density
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6980859/
https://www.ncbi.nlm.nih.gov/pubmed/32021080
http://dx.doi.org/10.2147/OPTH.S236041
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