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Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation

Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions...

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Detalles Bibliográficos
Autores principales: Chase, Henry W, Boudewyn, Megan A., Carter, Cameron S., Phillips, Mary L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981019/
https://www.ncbi.nlm.nih.gov/pubmed/31455860
http://dx.doi.org/10.1038/s41380-019-0499-9
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author Chase, Henry W
Boudewyn, Megan A.
Carter, Cameron S.
Phillips, Mary L.
author_facet Chase, Henry W
Boudewyn, Megan A.
Carter, Cameron S.
Phillips, Mary L.
author_sort Chase, Henry W
collection PubMed
description Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify key priorities for future research into major depression and schizophrenia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the establishment of the cognitive impact of tDCS, as well as investigations of the potential clinical efficacy of tDCS. We highlight areas of progress in each of these domains, including data which appears to favor an effect of tDCS on neural oscillations rather than spiking, and findings that tDCS administration to the prefrontal cortex during task training may be an effective way to enhance behavioral performance. Finally, we provide suggestions for further empirical study that will elucidate the impact of tDCS on brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorders.
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spelling pubmed-69810192020-02-27 Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation Chase, Henry W Boudewyn, Megan A. Carter, Cameron S. Phillips, Mary L. Mol Psychiatry Article Transcranial direct current stimulation (tDCS) is a promising method for altering the function of neural systems, cognition, and behavior. Evidence is emerging that it can also influence psychiatric symptomatology, including major depression and schizophrenia. However, there are many open questions regarding how the method might have such an effect, and uncertainties surrounding its influence on neural activity, and human cognition and functioning. In the present critical review, we identify key priorities for future research into major depression and schizophrenia, including studies of the mechanism(s) of action of tDCS at the neuronal and systems levels, the establishment of the cognitive impact of tDCS, as well as investigations of the potential clinical efficacy of tDCS. We highlight areas of progress in each of these domains, including data which appears to favor an effect of tDCS on neural oscillations rather than spiking, and findings that tDCS administration to the prefrontal cortex during task training may be an effective way to enhance behavioral performance. Finally, we provide suggestions for further empirical study that will elucidate the impact of tDCS on brain and behavior, and may pave the way for efficacious clinical treatments for psychiatric disorders. 2019-08-27 2020-02 /pmc/articles/PMC6981019/ /pubmed/31455860 http://dx.doi.org/10.1038/s41380-019-0499-9 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Chase, Henry W
Boudewyn, Megan A.
Carter, Cameron S.
Phillips, Mary L.
Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title_full Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title_fullStr Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title_full_unstemmed Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title_short Transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
title_sort transcranial direct current stimulation: a roadmap for research, from mechanism of action to clinical implementation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981019/
https://www.ncbi.nlm.nih.gov/pubmed/31455860
http://dx.doi.org/10.1038/s41380-019-0499-9
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