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Inhibition of hypoxia-inducible factor 1α accumulation by glyceryl trinitrate and cyclic guanosine monophosphate

A key mechanism mediating cellular adaptive responses to hypoxia involves the activity of hypoxia-inducible factor 1 (HIF-1), a transcription factor composed of HIF-1α, and HIF-1β subunits. The classical mechanism of regulation of HIF-1 activity involves destabilisation of HIF-1α via oxygen-dependen...

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Detalles Bibliográficos
Autores principales:	Kim, Judy, Barsoum, Ivraym B., Loh, Harrison, Paré, Jean-François, Siemens, D. Robert, Graham, Charles H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981098/ https://www.ncbi.nlm.nih.gov/pubmed/31912870 http://dx.doi.org/10.1042/BSR20192345

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