CD73 on cancer-associated fibroblasts enhanced by the A(2B)-mediated feedforward circuit enforces an immune checkpoint

CD73, an ecto-5′-nucleotidase (NT5E), serves as an immune checkpoint by generating adenosine (ADO), which suppresses immune activation through the A(2A) receptor. Elevated CD73 levels in tumor tissues correlate with poor clinical outcomes. However, the crucial source of CD73 activity within the tumo...

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Detalles Bibliográficos
Autores principales: Yu, Miao, Guo, Gang, Huang, Lei, Deng, Libin, Chang, Chang-Sheng, Achyut, Bhagelu R., Canning, Madison, Xu, Ningchun, Arbab, Ali S., Bollag, Roni J., Rodriguez, Paulo C., Mellor, Andrew L., Shi, Huidong, Munn, David H., Cui, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981126/
https://www.ncbi.nlm.nih.gov/pubmed/31980601
http://dx.doi.org/10.1038/s41467-019-14060-x

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