Impaired neuronal sodium channels cause intranodal conduction failure and reentrant arrhythmias in human sinoatrial node

Mechanisms for human sinoatrial node (SAN) dysfunction are poorly understood and whether human SAN excitability requires voltage-gated sodium channels (Nav) remains controversial. Here, we report that neuronal (n)Nav blockade and selective nNav1.6 blockade during high-resolution optical mapping in e...

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Detalles Bibliográficos
Autores principales: Li, Ning, Kalyanasundaram, Anuradha, Hansen, Brian J., Artiga, Esthela J., Sharma, Roshan, Abudulwahed, Suhaib H., Helfrich, Katelynn M., Rozenberg, Galina, Wu, Pei-Jung, Zakharkin, Stanislav, Gyorke, Sandor, Janssen, Paul ML., Whitson, Bryan A., Mokadam, Nahush A., Biesiadecki, Brandon J., Accornero, Federica, Hummel, John D., Mohler, Peter J., Dobrzynski, Halina, Zhao, Jichao, Fedorov, Vadim V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981137/
https://www.ncbi.nlm.nih.gov/pubmed/31980605
http://dx.doi.org/10.1038/s41467-019-14039-8

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