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Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome
Mutations in the actively expressed, maternal allele of the imprinted KCNK9 gene cause Birk-Barel intellectual disability syndrome (BBIDS). Using a BBIDS mouse model, we identify here a partial rescue of the BBIDS-like behavioral and neuronal phenotypes mediated via residual expression from the pate...
Autores principales: | Cooper, Alexis, Butto, Tamer, Hammer, Niklas, Jagannath, Somanath, Fend-Guella, Desiree Lucia, Akhtar, Junaid, Radyushkin, Konstantin, Lesage, Florian, Winter, Jennifer, Strand, Susanne, Roeper, Jochen, Zechner, Ulrich, Schweiger, Susann |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981138/ https://www.ncbi.nlm.nih.gov/pubmed/31980599 http://dx.doi.org/10.1038/s41467-019-13918-4 |
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