Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway

Congenital scoliosis (CS) is a complex genetic disorder characterized by vertebral malformations. The precise etiology of CS is not fully defined. Here, we identify that mutation in dual serine/threonine and tyrosine protein kinase (dstyk) lead to CS-like vertebral malformations in zebrafish. We dem...

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Detalles Bibliográficos
Autores principales: Sun, Xianding, Zhou, Yang, Zhang, Ruobin, Wang, Zuqiang, Xu, Meng, Zhang, Dali, Huang, Junlan, Luo, Fengtao, Li, Fangfang, Ni, Zhenhong, Zhou, Siru, Chen, Hangang, Chen, Shuai, Chen, Liang, Du, Xiaolan, Chen, Bo, Huang, Haiyang, Liu, Peng, Yin, Liangjun, Qiu, Juhui, Chen, Di, Deng, Chuxia, Xie, Yangli, Luo, Lingfei, Chen, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981171/
https://www.ncbi.nlm.nih.gov/pubmed/31980602
http://dx.doi.org/10.1038/s41467-019-14169-z

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