Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements

The trimeric HIV-1 Envelope protein (Env) mediates viral-host cell fusion via a network of conformational transitions, with allosteric elements in each protomer orchestrating host receptor-induced exposure of the co-receptor binding site and fusion elements. To understand the molecular details of th...

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Detalles Bibliográficos
Autores principales: Henderson, Rory, Lu, Maolin, Zhou, Ye, Mu, Zekun, Parks, Robert, Han, Qifeng, Hsu, Allen L., Carter, Elizabeth, Blanchard, Scott C., Edwards, R J, Wiehe, Kevin, Saunders, Kevin O., Borgnia, Mario J., Bartesaghi, Alberto, Mothes, Walther, Haynes, Barton F., Acharya, Priyamvada, Munir Alam, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981184/
https://www.ncbi.nlm.nih.gov/pubmed/31980614
http://dx.doi.org/10.1038/s41467-019-14196-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981184/
https://www.ncbi.nlm.nih.gov/pubmed/31980614
http://dx.doi.org/10.1038/s41467-019-14196-w

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