African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin

A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters...

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Detalles Bibliográficos
Autores principales: Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981190/
https://www.ncbi.nlm.nih.gov/pubmed/31980600
http://dx.doi.org/10.1038/s41467-019-14151-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981190/
https://www.ncbi.nlm.nih.gov/pubmed/31980600
http://dx.doi.org/10.1038/s41467-019-14151-9

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