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African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin
A variant at amino acid 47 in human TP53 exists predominantly in individuals of African descent. P47S human and mouse cells show increased cancer risk due to defective ferroptosis. Here, we show that this ferroptotic defect causes iron accumulation in P47S macrophages. This high iron content alters...
Autores principales: | Singh, Kumar Sachin, Leu, Julia I-Ju, Barnoud, Thibaut, Vonteddu, Prashanthi, Gnanapradeepan, Keerthana, Lin, Cindy, Liu, Qin, Barton, James C., Kossenkov, Andrew V., George, Donna L., Murphy, Maureen E., Dotiwala, Farokh |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981190/ https://www.ncbi.nlm.nih.gov/pubmed/31980600 http://dx.doi.org/10.1038/s41467-019-14151-9 |
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