GCAP neuronal calcium sensor proteins mediate photoreceptor cell death in the rd3 mouse model of LCA12 congenital blindness by involving endoplasmic reticulum stress

Loss-of-function mutations in the retinal degeneration 3 (RD3) gene cause inherited retinopathy with impaired rod and cone function and fast retinal degeneration in patients and in the natural strain of rd3 mice. The underlying physiopathology mechanisms are not well understood. We previously propos...

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Detalles Bibliográficos
Autores principales: Plana-Bonamaisó, Anna, López-Begines, Santiago, Andilla, Jordi, Fidalgo, María José, Loza-Alvarez, Pablo, Estanyol, Josep María, Villa, Pedro de la, Méndez, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981271/
https://www.ncbi.nlm.nih.gov/pubmed/31980596
http://dx.doi.org/10.1038/s41419-020-2255-0

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