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Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

The CRISPR system provides adaptive immunity against mobile genetic elements in prokaryotes. On binding invading RNA species, Type III CRISPR systems generate cyclic oligoadenylate (cOA) signalling molecules, potentiating a powerful immune response by activating downstream effector proteins, leading...

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Detalles Bibliográficos
Autores principales:	McMahon, Stephen A., Zhu, Wenlong, Graham, Shirley, Rambo, Robert, White, Malcolm F., Gloster, Tracey M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981274/ https://www.ncbi.nlm.nih.gov/pubmed/31980625 http://dx.doi.org/10.1038/s41467-019-14222-x

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