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DNA Repair and the Stability of the Plant Mitochondrial Genome
The mitochondrion stands at the center of cell energy metabolism. It contains its own genome, the mtDNA, that is a relic of its prokaryotic symbiotic ancestor. In plants, the mitochondrial genetic information influences important agronomic traits including fertility, plant vigor, chloroplast functio...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981420/ https://www.ncbi.nlm.nih.gov/pubmed/31947741 http://dx.doi.org/10.3390/ijms21010328 |
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author | Chevigny, Nicolas Schatz-Daas, Déborah Lotfi, Frédérique Gualberto, José Manuel |
author_facet | Chevigny, Nicolas Schatz-Daas, Déborah Lotfi, Frédérique Gualberto, José Manuel |
author_sort | Chevigny, Nicolas |
collection | PubMed |
description | The mitochondrion stands at the center of cell energy metabolism. It contains its own genome, the mtDNA, that is a relic of its prokaryotic symbiotic ancestor. In plants, the mitochondrial genetic information influences important agronomic traits including fertility, plant vigor, chloroplast function, and cross-compatibility. Plant mtDNA has remarkable characteristics: It is much larger than the mtDNA of other eukaryotes and evolves very rapidly in structure. This is because of recombination activities that generate alternative mtDNA configurations, an important reservoir of genetic diversity that promotes rapid mtDNA evolution. On the other hand, the high incidence of ectopic recombination leads to mtDNA instability and the expression of gene chimeras, with potential deleterious effects. In contrast to the structural plasticity of the genome, in most plant species the mtDNA coding sequences evolve very slowly, even if the organization of the genome is highly variable. Repair mechanisms are probably responsible for such low mutation rates, in particular repair by homologous recombination. Herein we review some of the characteristics of plant organellar genomes and of the repair pathways found in plant mitochondria. We further discuss how homologous recombination is involved in the evolution of the plant mtDNA. |
format | Online Article Text |
id | pubmed-6981420 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69814202020-02-07 DNA Repair and the Stability of the Plant Mitochondrial Genome Chevigny, Nicolas Schatz-Daas, Déborah Lotfi, Frédérique Gualberto, José Manuel Int J Mol Sci Review The mitochondrion stands at the center of cell energy metabolism. It contains its own genome, the mtDNA, that is a relic of its prokaryotic symbiotic ancestor. In plants, the mitochondrial genetic information influences important agronomic traits including fertility, plant vigor, chloroplast function, and cross-compatibility. Plant mtDNA has remarkable characteristics: It is much larger than the mtDNA of other eukaryotes and evolves very rapidly in structure. This is because of recombination activities that generate alternative mtDNA configurations, an important reservoir of genetic diversity that promotes rapid mtDNA evolution. On the other hand, the high incidence of ectopic recombination leads to mtDNA instability and the expression of gene chimeras, with potential deleterious effects. In contrast to the structural plasticity of the genome, in most plant species the mtDNA coding sequences evolve very slowly, even if the organization of the genome is highly variable. Repair mechanisms are probably responsible for such low mutation rates, in particular repair by homologous recombination. Herein we review some of the characteristics of plant organellar genomes and of the repair pathways found in plant mitochondria. We further discuss how homologous recombination is involved in the evolution of the plant mtDNA. MDPI 2020-01-03 /pmc/articles/PMC6981420/ /pubmed/31947741 http://dx.doi.org/10.3390/ijms21010328 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Chevigny, Nicolas Schatz-Daas, Déborah Lotfi, Frédérique Gualberto, José Manuel DNA Repair and the Stability of the Plant Mitochondrial Genome |
title | DNA Repair and the Stability of the Plant Mitochondrial Genome |
title_full | DNA Repair and the Stability of the Plant Mitochondrial Genome |
title_fullStr | DNA Repair and the Stability of the Plant Mitochondrial Genome |
title_full_unstemmed | DNA Repair and the Stability of the Plant Mitochondrial Genome |
title_short | DNA Repair and the Stability of the Plant Mitochondrial Genome |
title_sort | dna repair and the stability of the plant mitochondrial genome |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981420/ https://www.ncbi.nlm.nih.gov/pubmed/31947741 http://dx.doi.org/10.3390/ijms21010328 |
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