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Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain
Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was ind...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981426/ https://www.ncbi.nlm.nih.gov/pubmed/31948051 http://dx.doi.org/10.3390/ijms21010345 |
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author | Manukhina, Eugenia B. Tseilikman, Vadim E. Karpenko, Marina N. Pestereva, Nina S. Tseilikman, Olga B. Komelkova, Maria V. Kondashevskaya, Marina V. Goryacheva, Anna V. Lapshin, Maxim S. Platkovskii, Pavel O. Sarapultsev, Alexey P. Alliluev, Anatoly V. Downey, H. Fred |
author_facet | Manukhina, Eugenia B. Tseilikman, Vadim E. Karpenko, Marina N. Pestereva, Nina S. Tseilikman, Olga B. Komelkova, Maria V. Kondashevskaya, Marina V. Goryacheva, Anna V. Lapshin, Maxim S. Platkovskii, Pavel O. Sarapultsev, Alexey P. Alliluev, Anatoly V. Downey, H. Fred |
author_sort | Manukhina, Eugenia B. |
collection | PubMed |
description | Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC’s reduction of oxidative stress. |
format | Online Article Text |
id | pubmed-6981426 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69814262020-02-07 Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain Manukhina, Eugenia B. Tseilikman, Vadim E. Karpenko, Marina N. Pestereva, Nina S. Tseilikman, Olga B. Komelkova, Maria V. Kondashevskaya, Marina V. Goryacheva, Anna V. Lapshin, Maxim S. Platkovskii, Pavel O. Sarapultsev, Alexey P. Alliluev, Anatoly V. Downey, H. Fred Int J Mol Sci Article Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC’s ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC’s reduction of oxidative stress. MDPI 2020-01-05 /pmc/articles/PMC6981426/ /pubmed/31948051 http://dx.doi.org/10.3390/ijms21010345 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Manukhina, Eugenia B. Tseilikman, Vadim E. Karpenko, Marina N. Pestereva, Nina S. Tseilikman, Olga B. Komelkova, Maria V. Kondashevskaya, Marina V. Goryacheva, Anna V. Lapshin, Maxim S. Platkovskii, Pavel O. Sarapultsev, Alexey P. Alliluev, Anatoly V. Downey, H. Fred Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title | Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_full | Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_fullStr | Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_full_unstemmed | Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_short | Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain |
title_sort | intermittent hypoxic conditioning alleviates post-traumatic stress disorder-induced damage and dysfunction of rat visceral organs and brain |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981426/ https://www.ncbi.nlm.nih.gov/pubmed/31948051 http://dx.doi.org/10.3390/ijms21010345 |
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