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FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism....

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Autores principales: Seko, Yuya, Yano, Kohta, Takahashi, Aya, Okishio, Shinya, Kataoka, Seita, Okuda, Keiichiroh, Mizuno, Naoki, Takemura, Masashi, Taketani, Hiroyoshi, Umemura, Atsushi, Nishikawa, Taichiro, Yamaguchi, Kanji, Moriguchi, Michihisa, Okanoue, Takeshi, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981476/
https://www.ncbi.nlm.nih.gov/pubmed/31881781
http://dx.doi.org/10.3390/ijms21010171
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author Seko, Yuya
Yano, Kohta
Takahashi, Aya
Okishio, Shinya
Kataoka, Seita
Okuda, Keiichiroh
Mizuno, Naoki
Takemura, Masashi
Taketani, Hiroyoshi
Umemura, Atsushi
Nishikawa, Taichiro
Yamaguchi, Kanji
Moriguchi, Michihisa
Okanoue, Takeshi
Itoh, Yoshito
author_facet Seko, Yuya
Yano, Kohta
Takahashi, Aya
Okishio, Shinya
Kataoka, Seita
Okuda, Keiichiroh
Mizuno, Naoki
Takemura, Masashi
Taketani, Hiroyoshi
Umemura, Atsushi
Nishikawa, Taichiro
Yamaguchi, Kanji
Moriguchi, Michihisa
Okanoue, Takeshi
Itoh, Yoshito
author_sort Seko, Yuya
collection PubMed
description Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes.
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spelling pubmed-69814762020-02-07 FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease Seko, Yuya Yano, Kohta Takahashi, Aya Okishio, Shinya Kataoka, Seita Okuda, Keiichiroh Mizuno, Naoki Takemura, Masashi Taketani, Hiroyoshi Umemura, Atsushi Nishikawa, Taichiro Yamaguchi, Kanji Moriguchi, Michihisa Okanoue, Takeshi Itoh, Yoshito Int J Mol Sci Article Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes. MDPI 2019-12-25 /pmc/articles/PMC6981476/ /pubmed/31881781 http://dx.doi.org/10.3390/ijms21010171 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Seko, Yuya
Yano, Kohta
Takahashi, Aya
Okishio, Shinya
Kataoka, Seita
Okuda, Keiichiroh
Mizuno, Naoki
Takemura, Masashi
Taketani, Hiroyoshi
Umemura, Atsushi
Nishikawa, Taichiro
Yamaguchi, Kanji
Moriguchi, Michihisa
Okanoue, Takeshi
Itoh, Yoshito
FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title_full FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title_fullStr FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title_full_unstemmed FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title_short FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
title_sort fib-4 index and diabetes mellitus are associated with chronic kidney disease in japanese patients with non-alcoholic fatty liver disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981476/
https://www.ncbi.nlm.nih.gov/pubmed/31881781
http://dx.doi.org/10.3390/ijms21010171
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