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FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism....
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981476/ https://www.ncbi.nlm.nih.gov/pubmed/31881781 http://dx.doi.org/10.3390/ijms21010171 |
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author | Seko, Yuya Yano, Kohta Takahashi, Aya Okishio, Shinya Kataoka, Seita Okuda, Keiichiroh Mizuno, Naoki Takemura, Masashi Taketani, Hiroyoshi Umemura, Atsushi Nishikawa, Taichiro Yamaguchi, Kanji Moriguchi, Michihisa Okanoue, Takeshi Itoh, Yoshito |
author_facet | Seko, Yuya Yano, Kohta Takahashi, Aya Okishio, Shinya Kataoka, Seita Okuda, Keiichiroh Mizuno, Naoki Takemura, Masashi Taketani, Hiroyoshi Umemura, Atsushi Nishikawa, Taichiro Yamaguchi, Kanji Moriguchi, Michihisa Okanoue, Takeshi Itoh, Yoshito |
author_sort | Seko, Yuya |
collection | PubMed |
description | Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes. |
format | Online Article Text |
id | pubmed-6981476 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69814762020-02-07 FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease Seko, Yuya Yano, Kohta Takahashi, Aya Okishio, Shinya Kataoka, Seita Okuda, Keiichiroh Mizuno, Naoki Takemura, Masashi Taketani, Hiroyoshi Umemura, Atsushi Nishikawa, Taichiro Yamaguchi, Kanji Moriguchi, Michihisa Okanoue, Takeshi Itoh, Yoshito Int J Mol Sci Article Non-alcoholic fatty liver disease (NAFLD) is associated with chronic kidney disease (CKD). The aim of this retrospective study was to determine the risk factors for progression of CKD in patients with biopsy-proven NAFLD including patatin-like phospholipase domain containing 3 (PNPLA3) polymorphism. A total of 344 patients with biopsy-proven NAFLD were enrolled consecutively in this study. Multivariate analysis identified males (odds ratio (OR) 5.46), age (per 1 year, OR 1.07), and FIB-4 index (≥1.30, OR 3.85) as factors associated with CKD. Of the 154 patients with a baseline estimated glomerular filtration rate (eGFR) ≥60 mL/min, 30 had a deterioration in CKD stage and 15 developed CKD after 3 years. Multivariate analysis identified diabetes mellitus (OR 2.44) as a risk factor for deterioration in CKD stage, while diabetes mellitus (OR 21.54) and baseline eGFR (per 1 mL/min OR 0.88) were risk factors for development of CKD. PNPLA3 did not affect the change in eGFR. In NAFLD patients, a high FIB-4 index was associated with CKD to increases in the index linked to reductions in eGFR. In order to prevent development of CKD, an appropriate therapy focusing on renal function is needed for NAFLD patients, especially those with diabetes. MDPI 2019-12-25 /pmc/articles/PMC6981476/ /pubmed/31881781 http://dx.doi.org/10.3390/ijms21010171 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Seko, Yuya Yano, Kohta Takahashi, Aya Okishio, Shinya Kataoka, Seita Okuda, Keiichiroh Mizuno, Naoki Takemura, Masashi Taketani, Hiroyoshi Umemura, Atsushi Nishikawa, Taichiro Yamaguchi, Kanji Moriguchi, Michihisa Okanoue, Takeshi Itoh, Yoshito FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title_full | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title_fullStr | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title_full_unstemmed | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title_short | FIB-4 Index and Diabetes Mellitus Are Associated with Chronic Kidney Disease in Japanese Patients with Non-Alcoholic Fatty Liver Disease |
title_sort | fib-4 index and diabetes mellitus are associated with chronic kidney disease in japanese patients with non-alcoholic fatty liver disease |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981476/ https://www.ncbi.nlm.nih.gov/pubmed/31881781 http://dx.doi.org/10.3390/ijms21010171 |
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