Cargando…

Role of c-Jun N-Terminal Kinases (JNKs) in Epilepsy and Metabolic Cognitive Impairment

Previous studies have reported that the regulatory function of the different c-Jun N-terminal kinases isoforms (JNK1, JNK2, and JNK3) play an essential role in neurological disorders, such as epilepsy and metabolic-cognitive alterations. Accordingly, JNKs have emerged as suitable therapeutic strateg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Busquets, Oriol, Ettcheto, Miren, Cano, Amanda, R. Manzine, Patricia, Sánchez-Lopez, Elena, Espinosa-Jiménez, Triana, Verdaguer, Ester, Dario Castro-Torres, Rubén, Beas-Zarate, Carlos, X. Sureda, Francesc, Olloquequi, Jordi, Auladell, Carme, Folch, Jaume, Camins, Antoni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981493/ https://www.ncbi.nlm.nih.gov/pubmed/31905931 http://dx.doi.org/10.3390/ijms21010255

Ejemplares similares

Dexibuprofen ameliorates peripheral and central risk factors associated with Alzheimer’s disease in metabolically stressed APPswe/PS1dE9 mice
por: Ettcheto, Miren, et al.
Publicado: (2021)

The Implication of the Brain Insulin Receptor in Late Onset Alzheimer’s Disease Dementia
por: Folch, Jaume, et al.
Publicado: (2018)

Involvement of JNK1 in Neuronal Polarization During Brain Development
por: Castro-Torres, Rubén Darío, et al.
Publicado: (2020)

JNK1 and JNK3: divergent functions in hippocampal metabolic-cognitive function
por: Busquets, Oriol, et al.
Publicado: (2022)

Peroxisomal Proliferator-Activated Receptor β/δ Deficiency Induces Cognitive Alterations
por: Espinosa-Jiménez, Triana, et al.
Publicado: (2022)

The Involvement of Peripheral and Brain Insulin Resistance in Late Onset Alzheimer’s Dementia
por: Folch, Jaume, et al.
Publicado: (2019)

Experimental Models for Aging and their Potential for Novel Drug Discovery
por: Folch, Jaume, et al.
Publicado: (2018)

Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
por: Ettcheto, Miren, et al.
Publicado: (2017)

Memantine for the Treatment of Dementia: A Review on its Current and Future Applications
por: Folch, Jaume, et al.
Publicado: (2018)

Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia
por: Ettcheto, Miren, et al.
Publicado: (2020)

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet
por: Espinosa-Jiménez, Triana, et al.
Publicado: (2023)

Current Research Therapeutic Strategies for Alzheimer's Disease Treatment
por: Folch, Jaume, et al.
Publicado: (2016)

Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment
por: Olloquequi, Jordi, et al.
Publicado: (2023)

Dual Mkk4 and Mkk7 Gene Deletion in Adult Mouse Causes an Impairment of Hippocampal Immature Granule Cells
por: Castro-Torres, Rubén Darío, et al.
Publicado: (2021)

Potential preventive disease-modifying pharmacological strategies to delay late onset Alzheimer's disease
por: Ettcheto, Miren, et al.
Publicado: (2019)

Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment
por: Poor, Saghar Rabiei, et al.
Publicado: (2021)

Dual-drug loaded nanoparticles of Epigallocatechin-3-gallate (EGCG)/Ascorbic acid enhance therapeutic efficacy of EGCG in a APPswe/PS1dE9 Alzheimer's disease mice model
por: Cano, Amanda, et al.
Publicado: (2019)

The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies
por: Rayatpour, Atefeh, et al.
Publicado: (2021)

c-Jun N-Terminal Kinases (JNKs) in Myocardial and Cerebral Ischemia/Reperfusion Injury
por: Shvedova, Maria, et al.
Publicado: (2018)

Resveratrol: An Antiaging Drug with Potential Therapeutic Applications in Treating Diseases
por: Camins, Antoni, et al.
Publicado: (2009)

Metformin restores cognitive dysfunction and histopathological deficits in an animal model of sporadic Alzheimer's disease
por: Rabieipoor, Saghar, et al.
Publicado: (2023)

Lipid Nanoparticles for the Posterior Eye Segment
por: Bonilla, Lorena, et al.
Publicado: (2021)

Development of Peptide Targeted PLGA-PEGylated Nanoparticles Loading Licochalcone-A for Ocular Inflammation
por: Galindo, Ruth, et al.
Publicado: (2022)

Biodegradable nanoparticles for the treatment of epilepsy: From current advances to future challenges
por: Bonilla, Lorena, et al.
Publicado: (2021)

State-of-the-art polymeric nanoparticles as promising therapeutic tools against human bacterial infections
por: Cano, Amanda, et al.
Publicado: (2020)

JNKs protect from cholestatic liver disease progression by modulating Apelin signalling
por: Mohamed, Mohamed Ramadan, et al.
Publicado: (2023)

Exosomes-Based Nanomedicine for Neurodegenerative Diseases: Current Insights and Future Challenges
por: Cano, Amanda, et al.
Publicado: (2023)

Current Applications of Nanoemulsions in Cancer Therapeutics
por: Sánchez-López, Elena, et al.
Publicado: (2019)

State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparticles and Strategies to Reduce Toxicological Risks
por: García-Torra, Victor, et al.
Publicado: (2021)

Activation of JNKs is essential for BMP9-induced osteogenic differentiation of mesenchymal stem cells
por: Zhao, Yan-fang, et al.
Publicado: (2013)

JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21
por: Colleoni, B, et al.
Publicado: (2017)

Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment
por: Peron, Rafaela, et al.
Publicado: (2018)

A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286
por: Pizarro, Javier G, et al.
Publicado: (2009)

PDRPS7 protects cardiac cells from hypoxia/reoxygenation injury through inactivation of JNKs
por: Duan, Yulian, et al.
Publicado: (2020)

MKK7-mediated phosphorylation of JNKs regulates the proliferation and apoptosis of human spermatogonial stem cells
por: Huang, Zeng-Hui, et al.
Publicado: (2021)

Memantine loaded PLGA PEGylated nanoparticles for Alzheimer’s disease: in vitro and in vivo characterization
por: Sánchez-López, Elena, et al.
Publicado: (2018)

Extracellular vesicles, the emerging mirrors of brain physiopathology
por: Cano, Amanda, et al.
Publicado: (2023)

Understanding the Role of Hypoxia Inducible Factor During Neuro-degeneration for New Therapeutics Opportunities
por: Merelli, Amalia, et al.
Publicado: (2018)

Activation of the JNKs/ATM-p53 axis is indispensable for the cytoprotection of dermal fibroblasts exposed to UVB radiation
por: Mavrogonatou, Eleni, et al.
Publicado: (2022)

KB-R7943 reduces 4-aminopyridine-induced epileptiform activity in adult rats after neuronal damage induced by neonatal monosodium glutamate treatment
por: Hernandez-Ojeda, Mariana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_hsd26p86l2mjo87hl4fuhqgcbf