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Evolving a Peptide: Library Platforms and Diversification Strategies

Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specif...

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Detalles Bibliográficos
Autores principales: Bozovičar, Krištof, Bratkovič, Tomaž
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981544/
https://www.ncbi.nlm.nih.gov/pubmed/31892275
http://dx.doi.org/10.3390/ijms21010215
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author Bozovičar, Krištof
Bratkovič, Tomaž
author_facet Bozovičar, Krištof
Bratkovič, Tomaž
author_sort Bozovičar, Krištof
collection PubMed
description Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions.
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spelling pubmed-69815442020-02-03 Evolving a Peptide: Library Platforms and Diversification Strategies Bozovičar, Krištof Bratkovič, Tomaž Int J Mol Sci Review Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions. MDPI 2019-12-27 /pmc/articles/PMC6981544/ /pubmed/31892275 http://dx.doi.org/10.3390/ijms21010215 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bozovičar, Krištof
Bratkovič, Tomaž
Evolving a Peptide: Library Platforms and Diversification Strategies
title Evolving a Peptide: Library Platforms and Diversification Strategies
title_full Evolving a Peptide: Library Platforms and Diversification Strategies
title_fullStr Evolving a Peptide: Library Platforms and Diversification Strategies
title_full_unstemmed Evolving a Peptide: Library Platforms and Diversification Strategies
title_short Evolving a Peptide: Library Platforms and Diversification Strategies
title_sort evolving a peptide: library platforms and diversification strategies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981544/
https://www.ncbi.nlm.nih.gov/pubmed/31892275
http://dx.doi.org/10.3390/ijms21010215
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