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Evolving a Peptide: Library Platforms and Diversification Strategies
Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specif...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981544/ https://www.ncbi.nlm.nih.gov/pubmed/31892275 http://dx.doi.org/10.3390/ijms21010215 |
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author | Bozovičar, Krištof Bratkovič, Tomaž |
author_facet | Bozovičar, Krištof Bratkovič, Tomaž |
author_sort | Bozovičar, Krištof |
collection | PubMed |
description | Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions. |
format | Online Article Text |
id | pubmed-6981544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69815442020-02-03 Evolving a Peptide: Library Platforms and Diversification Strategies Bozovičar, Krištof Bratkovič, Tomaž Int J Mol Sci Review Peptides are widely used in pharmaceutical industry as active pharmaceutical ingredients, versatile tools in drug discovery, and for drug delivery. They find themselves at the crossroads of small molecules and proteins, possessing favorable tissue penetration and the capability to engage into specific and high-affinity interactions with endogenous receptors. One of the commonly employed approaches in peptide discovery and design is to screen combinatorial libraries, comprising a myriad of peptide variants of either chemical or biological origin. In this review, we focus mainly on recombinant peptide libraries, discussing different platforms for their display or expression, and various diversification strategies for library design. We take a look at well-established technologies as well as new developments and future directions. MDPI 2019-12-27 /pmc/articles/PMC6981544/ /pubmed/31892275 http://dx.doi.org/10.3390/ijms21010215 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bozovičar, Krištof Bratkovič, Tomaž Evolving a Peptide: Library Platforms and Diversification Strategies |
title | Evolving a Peptide: Library Platforms and Diversification Strategies |
title_full | Evolving a Peptide: Library Platforms and Diversification Strategies |
title_fullStr | Evolving a Peptide: Library Platforms and Diversification Strategies |
title_full_unstemmed | Evolving a Peptide: Library Platforms and Diversification Strategies |
title_short | Evolving a Peptide: Library Platforms and Diversification Strategies |
title_sort | evolving a peptide: library platforms and diversification strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981544/ https://www.ncbi.nlm.nih.gov/pubmed/31892275 http://dx.doi.org/10.3390/ijms21010215 |
work_keys_str_mv | AT bozovicarkristof evolvingapeptidelibraryplatformsanddiversificationstrategies AT bratkovictomaz evolvingapeptidelibraryplatformsanddiversificationstrategies |