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PP2A Functions during Mitosis and Cytokinesis in Yeasts

Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential ro...

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Detalles Bibliográficos
Autores principales: Moyano-Rodriguez, Yolanda, Queralt, Ethel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981662/
https://www.ncbi.nlm.nih.gov/pubmed/31906018
http://dx.doi.org/10.3390/ijms21010264
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author Moyano-Rodriguez, Yolanda
Queralt, Ethel
author_facet Moyano-Rodriguez, Yolanda
Queralt, Ethel
author_sort Moyano-Rodriguez, Yolanda
collection PubMed
description Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential roles in cell growth, proliferation, and regulation of the cell cycle. Here, we review the function of the protein phosphatase 2A family as the counteracting force for the mitotic kinases. We focus on recent findings in the regulation of mitotic exit and cytokinesis by PP2A phosphatases in S. cerevisiae and other fungal species.
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spelling pubmed-69816622020-02-03 PP2A Functions during Mitosis and Cytokinesis in Yeasts Moyano-Rodriguez, Yolanda Queralt, Ethel Int J Mol Sci Review Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential roles in cell growth, proliferation, and regulation of the cell cycle. Here, we review the function of the protein phosphatase 2A family as the counteracting force for the mitotic kinases. We focus on recent findings in the regulation of mitotic exit and cytokinesis by PP2A phosphatases in S. cerevisiae and other fungal species. MDPI 2019-12-30 /pmc/articles/PMC6981662/ /pubmed/31906018 http://dx.doi.org/10.3390/ijms21010264 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moyano-Rodriguez, Yolanda
Queralt, Ethel
PP2A Functions during Mitosis and Cytokinesis in Yeasts
title PP2A Functions during Mitosis and Cytokinesis in Yeasts
title_full PP2A Functions during Mitosis and Cytokinesis in Yeasts
title_fullStr PP2A Functions during Mitosis and Cytokinesis in Yeasts
title_full_unstemmed PP2A Functions during Mitosis and Cytokinesis in Yeasts
title_short PP2A Functions during Mitosis and Cytokinesis in Yeasts
title_sort pp2a functions during mitosis and cytokinesis in yeasts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981662/
https://www.ncbi.nlm.nih.gov/pubmed/31906018
http://dx.doi.org/10.3390/ijms21010264
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