Cargando…
PP2A Functions during Mitosis and Cytokinesis in Yeasts
Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential ro...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981662/ https://www.ncbi.nlm.nih.gov/pubmed/31906018 http://dx.doi.org/10.3390/ijms21010264 |
_version_ | 1783491133420077056 |
---|---|
author | Moyano-Rodriguez, Yolanda Queralt, Ethel |
author_facet | Moyano-Rodriguez, Yolanda Queralt, Ethel |
author_sort | Moyano-Rodriguez, Yolanda |
collection | PubMed |
description | Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential roles in cell growth, proliferation, and regulation of the cell cycle. Here, we review the function of the protein phosphatase 2A family as the counteracting force for the mitotic kinases. We focus on recent findings in the regulation of mitotic exit and cytokinesis by PP2A phosphatases in S. cerevisiae and other fungal species. |
format | Online Article Text |
id | pubmed-6981662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69816622020-02-03 PP2A Functions during Mitosis and Cytokinesis in Yeasts Moyano-Rodriguez, Yolanda Queralt, Ethel Int J Mol Sci Review Protein phosphorylation is a common mechanism for the regulation of cell cycle progression. The opposing functions of cell cycle kinases and phosphatases are crucial for accurate chromosome segregation and exit from mitosis. Protein phosphatases 2A are heterotrimeric complexes that play essential roles in cell growth, proliferation, and regulation of the cell cycle. Here, we review the function of the protein phosphatase 2A family as the counteracting force for the mitotic kinases. We focus on recent findings in the regulation of mitotic exit and cytokinesis by PP2A phosphatases in S. cerevisiae and other fungal species. MDPI 2019-12-30 /pmc/articles/PMC6981662/ /pubmed/31906018 http://dx.doi.org/10.3390/ijms21010264 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Moyano-Rodriguez, Yolanda Queralt, Ethel PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title | PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title_full | PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title_fullStr | PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title_full_unstemmed | PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title_short | PP2A Functions during Mitosis and Cytokinesis in Yeasts |
title_sort | pp2a functions during mitosis and cytokinesis in yeasts |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981662/ https://www.ncbi.nlm.nih.gov/pubmed/31906018 http://dx.doi.org/10.3390/ijms21010264 |
work_keys_str_mv | AT moyanorodriguezyolanda pp2afunctionsduringmitosisandcytokinesisinyeasts AT queraltethel pp2afunctionsduringmitosisandcytokinesisinyeasts |