Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy

Humans with dilated cardiomyopathy (DCM) and heart failure (HF) develop low levels of corin, a multi-domain, cardiac-selective serine protease involved in natriuretic peptide cleavage and sodium and water regulation. However, experimental restoration of corin levels markedly attenuates HF progressio...

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Detalles Bibliográficos
Autores principales: Tripathi, Ranjana, Sullivan, Ryan D., Fan, Tai-Hwang M., Houng, Aiilyan K., Mehta, Radhika M., Reed, Guy L., Gladysheva, Inna P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981738/
https://www.ncbi.nlm.nih.gov/pubmed/31892216
http://dx.doi.org/10.3390/ijms21010203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981738/
https://www.ncbi.nlm.nih.gov/pubmed/31892216
http://dx.doi.org/10.3390/ijms21010203

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