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Cardiac-Specific Overexpression of Catalytically Inactive Corin Reduces Edema, Contractile Dysfunction, and Death in Mice with Dilated Cardiomyopathy
Humans with dilated cardiomyopathy (DCM) and heart failure (HF) develop low levels of corin, a multi-domain, cardiac-selective serine protease involved in natriuretic peptide cleavage and sodium and water regulation. However, experimental restoration of corin levels markedly attenuates HF progressio...
Autores principales: | Tripathi, Ranjana, Sullivan, Ryan D., Fan, Tai-Hwang M., Houng, Aiilyan K., Mehta, Radhika M., Reed, Guy L., Gladysheva, Inna P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981738/ https://www.ncbi.nlm.nih.gov/pubmed/31892216 http://dx.doi.org/10.3390/ijms21010203 |
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