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Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain

Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate’s health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate’s effects against Parkinson’s...

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Autores principales: Kujawska, Małgorzata, Jourdes, Michael, Kurpik, Monika, Szulc, Michał, Szaefer, Hanna, Chmielarz, Piotr, Kreiner, Grzegorz, Krajka-Kuźniak, Violetta, Mikołajczak, Przemyslaw Łukasz, Teissedre, Pierre-Louis, Jodynis-Liebert, Jadwiga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981883/
https://www.ncbi.nlm.nih.gov/pubmed/31892167
http://dx.doi.org/10.3390/ijms21010202
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author Kujawska, Małgorzata
Jourdes, Michael
Kurpik, Monika
Szulc, Michał
Szaefer, Hanna
Chmielarz, Piotr
Kreiner, Grzegorz
Krajka-Kuźniak, Violetta
Mikołajczak, Przemyslaw Łukasz
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
author_facet Kujawska, Małgorzata
Jourdes, Michael
Kurpik, Monika
Szulc, Michał
Szaefer, Hanna
Chmielarz, Piotr
Kreiner, Grzegorz
Krajka-Kuźniak, Violetta
Mikołajczak, Przemyslaw Łukasz
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
author_sort Kujawska, Małgorzata
collection PubMed
description Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate’s health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites—urolithins. In this study, we examined the capability of pomegranate juice for protection against PD in a rat model of parkinsonism induced by rotenone. To evaluate its efficiency, assessment of postural instability, visualization of neurodegeneration, determination of oxidative damage to lipids and α-synuclein level, as well as markers of antioxidant defense status, inflammation, and apoptosis, were performed in the midbrain. We also check the presence of plausible active pomegranate ETs-derived metabolite, urolithin A, in the plasma and brain. Our results indicated that pomegranate juice treatment provided neuroprotection as evidenced by the postural stability improvement, enhancement of neuronal survival, its protection against oxidative damage and α-synuclein aggregation, the increase in mitochondrial aldehyde dehydrogenase activity, and maintenance of antiapoptotic Bcl-xL protein at the control level. In addition, we have provided evidence for the distribution of urolithin A to the brain.
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spelling pubmed-69818832020-02-07 Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain Kujawska, Małgorzata Jourdes, Michael Kurpik, Monika Szulc, Michał Szaefer, Hanna Chmielarz, Piotr Kreiner, Grzegorz Krajka-Kuźniak, Violetta Mikołajczak, Przemyslaw Łukasz Teissedre, Pierre-Louis Jodynis-Liebert, Jadwiga Int J Mol Sci Article Pomegranate juice is a rich source of ellagitannins (ETs) believed to contribute to a wide range of pomegranate’s health benefits. While a lot of experimental studies have been devoted to Alzheimer disease and hypoxic-ischemic brain injury, our knowledge of pomegranate’s effects against Parkinson’s disease (PD) is very limited. It is suggested that its neuroprotective effects are mediated by ETs-derived metabolites—urolithins. In this study, we examined the capability of pomegranate juice for protection against PD in a rat model of parkinsonism induced by rotenone. To evaluate its efficiency, assessment of postural instability, visualization of neurodegeneration, determination of oxidative damage to lipids and α-synuclein level, as well as markers of antioxidant defense status, inflammation, and apoptosis, were performed in the midbrain. We also check the presence of plausible active pomegranate ETs-derived metabolite, urolithin A, in the plasma and brain. Our results indicated that pomegranate juice treatment provided neuroprotection as evidenced by the postural stability improvement, enhancement of neuronal survival, its protection against oxidative damage and α-synuclein aggregation, the increase in mitochondrial aldehyde dehydrogenase activity, and maintenance of antiapoptotic Bcl-xL protein at the control level. In addition, we have provided evidence for the distribution of urolithin A to the brain. MDPI 2019-12-27 /pmc/articles/PMC6981883/ /pubmed/31892167 http://dx.doi.org/10.3390/ijms21010202 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kujawska, Małgorzata
Jourdes, Michael
Kurpik, Monika
Szulc, Michał
Szaefer, Hanna
Chmielarz, Piotr
Kreiner, Grzegorz
Krajka-Kuźniak, Violetta
Mikołajczak, Przemyslaw Łukasz
Teissedre, Pierre-Louis
Jodynis-Liebert, Jadwiga
Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title_full Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title_fullStr Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title_full_unstemmed Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title_short Neuroprotective Effects of Pomegranate Juice against Parkinson’s Disease and Presence of Ellagitannins-Derived Metabolite—Urolithin A—In the Brain
title_sort neuroprotective effects of pomegranate juice against parkinson’s disease and presence of ellagitannins-derived metabolite—urolithin a—in the brain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981883/
https://www.ncbi.nlm.nih.gov/pubmed/31892167
http://dx.doi.org/10.3390/ijms21010202
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