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Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics
The apparent lack of success in curing cancer that was evidenced in the last four decades of molecular medicine indicates the need for a global re-thinking both its nature and the biological approaches that we are taking in its solution. The reductionist, one gene/one protein method that has served...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981914/ https://www.ncbi.nlm.nih.gov/pubmed/31905791 http://dx.doi.org/10.3390/ijms21010240 |
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author | Erenpreisa, Jekaterina Giuliani, Alessandro |
author_facet | Erenpreisa, Jekaterina Giuliani, Alessandro |
author_sort | Erenpreisa, Jekaterina |
collection | PubMed |
description | The apparent lack of success in curing cancer that was evidenced in the last four decades of molecular medicine indicates the need for a global re-thinking both its nature and the biological approaches that we are taking in its solution. The reductionist, one gene/one protein method that has served us well until now, and that still dominates in biomedicine, requires complementation with a more systemic/holistic approach, to address the huge problem of cross-talk between more than 20,000 protein-coding genes, about 100,000 protein types, and the multiple layers of biological organization. In this perspective, the relationship between the chromatin network organization and gene expression regulation plays a fundamental role. The elucidation of such a relationship requires a non-linear thermodynamics approach to these biological systems. This change of perspective is a necessary step for developing successful ‘tumour-reversion’ therapeutic strategies. |
format | Online Article Text |
id | pubmed-6981914 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69819142020-02-07 Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics Erenpreisa, Jekaterina Giuliani, Alessandro Int J Mol Sci Review The apparent lack of success in curing cancer that was evidenced in the last four decades of molecular medicine indicates the need for a global re-thinking both its nature and the biological approaches that we are taking in its solution. The reductionist, one gene/one protein method that has served us well until now, and that still dominates in biomedicine, requires complementation with a more systemic/holistic approach, to address the huge problem of cross-talk between more than 20,000 protein-coding genes, about 100,000 protein types, and the multiple layers of biological organization. In this perspective, the relationship between the chromatin network organization and gene expression regulation plays a fundamental role. The elucidation of such a relationship requires a non-linear thermodynamics approach to these biological systems. This change of perspective is a necessary step for developing successful ‘tumour-reversion’ therapeutic strategies. MDPI 2019-12-29 /pmc/articles/PMC6981914/ /pubmed/31905791 http://dx.doi.org/10.3390/ijms21010240 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Erenpreisa, Jekaterina Giuliani, Alessandro Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title | Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title_full | Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title_fullStr | Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title_full_unstemmed | Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title_short | Resolution of Complex Issues in Genome Regulation and Cancer Requires Non-Linear and Network-Based Thermodynamics |
title_sort | resolution of complex issues in genome regulation and cancer requires non-linear and network-based thermodynamics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981914/ https://www.ncbi.nlm.nih.gov/pubmed/31905791 http://dx.doi.org/10.3390/ijms21010240 |
work_keys_str_mv | AT erenpreisajekaterina resolutionofcomplexissuesingenomeregulationandcancerrequiresnonlinearandnetworkbasedthermodynamics AT giulianialessandro resolutionofcomplexissuesingenomeregulationandcancerrequiresnonlinearandnetworkbasedthermodynamics |