miR-218 Inhibits Mitochondrial Clearance by Targeting PRKN E3 Ubiquitin Ligase

The selective elimination of dysfunctional mitochondria through mitophagy is crucial for preserving mitochondrial quality and cellular homeostasis. The most described mitophagy pathway is regulated by a positive ubiquitylation feedback loop in which the PINK1 (PTEN induced kinase 1) kinase phosphory...

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Detalles Bibliográficos
Autores principales: Di Rita, Anthea, Maiorino, Teresa, Bruqi, Krenare, Volpicelli, Floriana, Bellenchi, Gian Carlo, Strappazzon, Flavie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981953/
https://www.ncbi.nlm.nih.gov/pubmed/31948106
http://dx.doi.org/10.3390/ijms21010355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6981953/
https://www.ncbi.nlm.nih.gov/pubmed/31948106
http://dx.doi.org/10.3390/ijms21010355

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