Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels

Changes in fetal DNA methylation (DNAm) of the leptin (LEP) gene have been associated with exposure to maternal hyperglycemia, but their links with childhood obesity risk are still unclear. We investigated the association between maternal hyperglycemia, placental LEP DNAm (25 5′-C-phosphate-G-3′ (Cp...

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Autores principales: Gagné-Ouellet, Valérie, Breton, Edith, Thibeault, Kathrine, Fortin, Carol-Ann, Cardenas, Andres, Guérin, Renée, Perron, Patrice, Hivert, Marie-France, Bouchard, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982090/
https://www.ncbi.nlm.nih.gov/pubmed/31947745
http://dx.doi.org/10.3390/ijms21010329

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