Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3

We report on the design, synthesis and molecular modeling study of conjugates of adenosine diphosphate (ADP) and morpholino nucleosides as potential selective inhibitors of poly(ADP-ribose)polymerases-1, 2 and 3. Sixteen dinucleoside pyrophosphates containing natural heterocyclic bases as well as 5-...

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Detalles Bibliográficos
Autores principales: Sherstyuk, Yuliya V., Ivanisenko, Nikita V., Zakharenko, Alexandra L., Sukhanova, Maria V., Peshkov, Roman Y., Eltsov, Ilia V., Kutuzov, Mikhail M., Kurgina, Tatiana A., Belousova, Ekaterina A., Ivanisenko, Vladimir A., Lavrik, Olga I., Silnikov, Vladimir N., Abramova, Tatyana V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982223/
https://www.ncbi.nlm.nih.gov/pubmed/31892271
http://dx.doi.org/10.3390/ijms21010214

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