Cargando…
TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling
VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, gene...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982260/ https://www.ncbi.nlm.nih.gov/pubmed/31878142 http://dx.doi.org/10.3390/ijms21010130 |
_version_ | 1783491274400071680 |
---|---|
author | Bresciani, Elena Possenti, Roberta Coco, Silvia Rizzi, Laura Meanti, Ramona Molteni, Laura Locatelli, Vittorio Torsello, Antonio |
author_facet | Bresciani, Elena Possenti, Roberta Coco, Silvia Rizzi, Laura Meanti, Ramona Molteni, Laura Locatelli, Vittorio Torsello, Antonio |
author_sort | Bresciani, Elena |
collection | PubMed |
description | VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca(2+). This effect relies both on Ca(2+) release from the endoplasmic reticulum (ER) and extracellular Ca(2+) entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca(2+) entry, the activation of outward K(+)-Ca(2+)-dependent currents, mainly the K(Ca3.1) currents, provides a membrane polarizing influence which offset the depolarizing action of Ca(2+) elevation and indirectly maintains the driving force for optimal Ca(2+) increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. |
format | Online Article Text |
id | pubmed-6982260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69822602020-02-07 TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling Bresciani, Elena Possenti, Roberta Coco, Silvia Rizzi, Laura Meanti, Ramona Molteni, Laura Locatelli, Vittorio Torsello, Antonio Int J Mol Sci Review VGF gene encodes for a neuropeptide precursor of 68 kDa composed by 615 (human) and 617 (rat, mice) residues, expressed prevalently in the central nervous system (CNS), but also in the peripheral nervous system (PNS) and in various endocrine cells. This precursor undergoes proteolytic cleavage, generating a family of peptides different in length and biological activity. Among them, TLQP-21, a peptide of 21 amino acids, has been widely investigated for its relevant endocrine and extraendocrine activities. The complement complement C3a receptor-1 (C3aR1) has been suggested as the TLQP-21 receptor and, in different cell lines, its activation by TLQP-21 induces an increase of intracellular Ca(2+). This effect relies both on Ca(2+) release from the endoplasmic reticulum (ER) and extracellular Ca(2+) entry. The latter depends on stromal interaction molecules (STIM)-Orai1 interaction or transient receptor potential channel (TRPC) involvement. After Ca(2+) entry, the activation of outward K(+)-Ca(2+)-dependent currents, mainly the K(Ca3.1) currents, provides a membrane polarizing influence which offset the depolarizing action of Ca(2+) elevation and indirectly maintains the driving force for optimal Ca(2+) increase in the cytosol. In this review, we address the main endocrine and extraendocrine actions displayed by TLQP-21, highlighting recent findings on its mechanism of action and its potential in different pathological conditions. MDPI 2019-12-24 /pmc/articles/PMC6982260/ /pubmed/31878142 http://dx.doi.org/10.3390/ijms21010130 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bresciani, Elena Possenti, Roberta Coco, Silvia Rizzi, Laura Meanti, Ramona Molteni, Laura Locatelli, Vittorio Torsello, Antonio TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title | TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title_full | TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title_fullStr | TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title_full_unstemmed | TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title_short | TLQP-21, A VGF-Derived Peptide Endowed of Endocrine and Extraendocrine Properties: Focus on In Vitro Calcium Signaling |
title_sort | tlqp-21, a vgf-derived peptide endowed of endocrine and extraendocrine properties: focus on in vitro calcium signaling |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982260/ https://www.ncbi.nlm.nih.gov/pubmed/31878142 http://dx.doi.org/10.3390/ijms21010130 |
work_keys_str_mv | AT brescianielena tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT possentiroberta tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT cocosilvia tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT rizzilaura tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT meantiramona tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT moltenilaura tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT locatellivittorio tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling AT torselloantonio tlqp21avgfderivedpeptideendowedofendocrineandextraendocrinepropertiesfocusoninvitrocalciumsignaling |