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Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors

Deregulation of receptor tyrosine kinase (RTK)-signaling is frequently observed in many human malignancies, making activated RTKs the promising therapeutic targets. In particular, activated RTK-signaling has a strong impact on tumor resistance to various DNA damaging agents, e.g., ionizing radiation...

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Detalles Bibliográficos
Autores principales:	Sergei, Boichuk, Pavel, Dunaev, Aigul, Galembikova, Firyuza, Bikinieva, Ilmira, Nurgatina, Ilshat, Mustafin, Aida, Aukhadieva, Refat, Kurtasanov, Natalia, Andriutsa, Elena, Shagimardanova, Vera, Gorbunova
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982350/ https://www.ncbi.nlm.nih.gov/pubmed/31948066 http://dx.doi.org/10.3390/ijms21010352

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