Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (Top1) poisons such as topotecan and irinotecan. Here...

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Detalles Bibliográficos
Autores principales: Khomenko, Tatyana M., Zakharenko, Alexandra L., Chepanova, Arina A., Ilina, Ekaterina S., Zakharova, Olga D., Kaledin, Vasily I., Nikolin, Valeriy P., Popova, Nelly A., Korchagina, Dina V., Reynisson, Jóhannes, Chand, Raina, Ayine-Tora, Daniel M., Patel, Jinal, Leung, Ivanhoe K. H., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982354/
https://www.ncbi.nlm.nih.gov/pubmed/31878088
http://dx.doi.org/10.3390/ijms21010126

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