Global targeting of functional tyrosines using sulfur triazole exchange chemistry

Covalent probes serve as valuable tools for global investigation of protein function and ligand binding capacity. Despite efforts to expand coverage of residues available for chemical proteomics (e.g. cysteine and lysine), a large fraction of the proteome remains inaccessible with current activity-b...

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Detalles Bibliográficos
Autores principales: Hahm, Heung Sik, Toroitich, Emmanuel K., Borne, Adam L., Brulet, Jeffrey W., Libby, Adam H., Yuan, Kun, Ware, Timothy B., McCloud, Rebecca L., Ciancone, Anthony M., Hsu, Ku-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982592/
https://www.ncbi.nlm.nih.gov/pubmed/31768034
http://dx.doi.org/10.1038/s41589-019-0404-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982592/
https://www.ncbi.nlm.nih.gov/pubmed/31768034
http://dx.doi.org/10.1038/s41589-019-0404-5

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