Cargando…

Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma

OBJECTIVE: Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there are obscuring factors and limited biopsy material. However, there is a consid...

Descripción completa

Detalles Bibliográficos
Autores principales: Atiq, Aribah, Mushtaq, Sajid, Hassan, Usman, Loya, Asif, Hussain, Mudassir, Akhter, Noreen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982655/
https://www.ncbi.nlm.nih.gov/pubmed/31653135
http://dx.doi.org/10.31557/APJCP.2019.20.10.2917
_version_ 1783491338281418752
author Atiq, Aribah
Mushtaq, Sajid
Hassan, Usman
Loya, Asif
Hussain, Mudassir
Akhter, Noreen
author_facet Atiq, Aribah
Mushtaq, Sajid
Hassan, Usman
Loya, Asif
Hussain, Mudassir
Akhter, Noreen
author_sort Atiq, Aribah
collection PubMed
description OBJECTIVE: Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there are obscuring factors and limited biopsy material. However, there is a considerable difference in treatment and prognosis, which raises the need to distinguish these two entities. In this study, we discuss the utility of two immunohistochemical stains, p63 and p40, in different combinations for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. MATERIALS AND METHODS: Two immunohistochemical stains, p63 and p40, were performed on 47 cases of adenoid cystic carcinoma and 23 cases of polymorphous adenocarcinoma. RESULTS: 36 out of 47 cases of adenoid cystic carcinoma showed p63+ve/p40+ve immunoprofile, followed by p63-ve/p40-ve immunoprofile, which is seen in10 cases of adenoid cystic carcinoma. However, 22 out of 23 cases of polymorphous adenocarcinoma displayed p63+ve/p40-ve immunoprofile. p63-ve/p40+ve is the least frequent observed immunoprofile, which is seen in only one case of adenoid cystic carcinoma. CONCLUSION: On combining all possible immunoprofile combinations, p63+ve/p40-ve immunoprofile appears to be the most sensitive profile for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma.
format Online
Article
Text
id pubmed-6982655
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher West Asia Organization for Cancer Prevention
record_format MEDLINE/PubMed
spelling pubmed-69826552020-07-07 Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma Atiq, Aribah Mushtaq, Sajid Hassan, Usman Loya, Asif Hussain, Mudassir Akhter, Noreen Asian Pac J Cancer Prev Research Article OBJECTIVE: Adenoid cystic carcinoma and polymorphous adenocarcinoma are primarily the tumor of minor salivary glands. Both show certain morphological similarities, which limit their proper diagnosis in settings where there are obscuring factors and limited biopsy material. However, there is a considerable difference in treatment and prognosis, which raises the need to distinguish these two entities. In this study, we discuss the utility of two immunohistochemical stains, p63 and p40, in different combinations for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. MATERIALS AND METHODS: Two immunohistochemical stains, p63 and p40, were performed on 47 cases of adenoid cystic carcinoma and 23 cases of polymorphous adenocarcinoma. RESULTS: 36 out of 47 cases of adenoid cystic carcinoma showed p63+ve/p40+ve immunoprofile, followed by p63-ve/p40-ve immunoprofile, which is seen in10 cases of adenoid cystic carcinoma. However, 22 out of 23 cases of polymorphous adenocarcinoma displayed p63+ve/p40-ve immunoprofile. p63-ve/p40+ve is the least frequent observed immunoprofile, which is seen in only one case of adenoid cystic carcinoma. CONCLUSION: On combining all possible immunoprofile combinations, p63+ve/p40-ve immunoprofile appears to be the most sensitive profile for distinguishing polymorphous adenocarcinoma from adenoid cystic carcinoma. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6982655/ /pubmed/31653135 http://dx.doi.org/10.31557/APJCP.2019.20.10.2917 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Atiq, Aribah
Mushtaq, Sajid
Hassan, Usman
Loya, Asif
Hussain, Mudassir
Akhter, Noreen
Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title_full Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title_fullStr Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title_full_unstemmed Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title_short Utility of p63 and p40 in Distinguishing Polymorphous Adenocarcinoma and Adenoid Cystic Carcinoma
title_sort utility of p63 and p40 in distinguishing polymorphous adenocarcinoma and adenoid cystic carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982655/
https://www.ncbi.nlm.nih.gov/pubmed/31653135
http://dx.doi.org/10.31557/APJCP.2019.20.10.2917
work_keys_str_mv AT atiqaribah utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma
AT mushtaqsajid utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma
AT hassanusman utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma
AT loyaasif utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma
AT hussainmudassir utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma
AT akhternoreen utilityofp63andp40indistinguishingpolymorphousadenocarcinomaandadenoidcysticcarcinoma