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Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM

BACKGROUND: Treatment of cancer with chemo-radiotherapy causes severe side effects due to cytotoxic effects towards normal tissues which often results in morbidity. Therefore, developing anticancer agents which can selectively target the cancer cells and cause less side effects are the main objectiv...

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Autores principales: Assayaghi, Rowa Mohammed, Alabsi, Aied Mohammed, Swethadri, Gumballi, Ali, Abdul Manaf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982671/
https://www.ncbi.nlm.nih.gov/pubmed/31653156
http://dx.doi.org/10.31557/APJCP.2019.20.10.3071
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author Assayaghi, Rowa Mohammed
Alabsi, Aied Mohammed
Swethadri, Gumballi
Ali, Abdul Manaf
author_facet Assayaghi, Rowa Mohammed
Alabsi, Aied Mohammed
Swethadri, Gumballi
Ali, Abdul Manaf
author_sort Assayaghi, Rowa Mohammed
collection PubMed
description BACKGROUND: Treatment of cancer with chemo-radiotherapy causes severe side effects due to cytotoxic effects towards normal tissues which often results in morbidity. Therefore, developing anticancer agents which can selectively target the cancer cells and cause less side effects are the main objectives of the new therapeutic strategies for treatment advanced or metastatic cancers. Newcastle disease virus strains AF2240 and V4-UPM were shown to be cytolytic against various cancer cells in-vitro and very effective as antileukemicagents. METHODS: 45 rats at 6 weeks of age, were randomly assigned to nine groups with 5 rats in each group, both azoxymethane (AOM) and 5-Fluorouracil (5-FU) were given to rats according to the body weight. NDV virus strains (AF2240 and V4-UPM) doses were determined to rats according to CD50 resulted from MTT assay. After 8 doses of NDV strians and 5-FU, tissue sections preparations and histopathological study of rats’ organs were done. RESULTS: In this article morphological changes of rats’ organs, especially in livers, after treatment with a colon carcinogen (azoxymethane) and Newcastle disease virus strains have been recorded. We observed liver damage caused by AOM evidenced by morphological changes and enzymatic elevation were protected by the oncolytic viruses sections. Also we found that combination treatment NDV with 5-FU had greater antitumor efficacy than treatment with NDV or 5-FU alone. CONCLUSION: We noted morphological changes in liver and other rats’ organs due to a chemical carcinogen and their protection by NDV AF2240 and NDV V4-UPM seems to be most protective.
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spelling pubmed-69826712020-07-07 Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM Assayaghi, Rowa Mohammed Alabsi, Aied Mohammed Swethadri, Gumballi Ali, Abdul Manaf Asian Pac J Cancer Prev Research Article BACKGROUND: Treatment of cancer with chemo-radiotherapy causes severe side effects due to cytotoxic effects towards normal tissues which often results in morbidity. Therefore, developing anticancer agents which can selectively target the cancer cells and cause less side effects are the main objectives of the new therapeutic strategies for treatment advanced or metastatic cancers. Newcastle disease virus strains AF2240 and V4-UPM were shown to be cytolytic against various cancer cells in-vitro and very effective as antileukemicagents. METHODS: 45 rats at 6 weeks of age, were randomly assigned to nine groups with 5 rats in each group, both azoxymethane (AOM) and 5-Fluorouracil (5-FU) were given to rats according to the body weight. NDV virus strains (AF2240 and V4-UPM) doses were determined to rats according to CD50 resulted from MTT assay. After 8 doses of NDV strians and 5-FU, tissue sections preparations and histopathological study of rats’ organs were done. RESULTS: In this article morphological changes of rats’ organs, especially in livers, after treatment with a colon carcinogen (azoxymethane) and Newcastle disease virus strains have been recorded. We observed liver damage caused by AOM evidenced by morphological changes and enzymatic elevation were protected by the oncolytic viruses sections. Also we found that combination treatment NDV with 5-FU had greater antitumor efficacy than treatment with NDV or 5-FU alone. CONCLUSION: We noted morphological changes in liver and other rats’ organs due to a chemical carcinogen and their protection by NDV AF2240 and NDV V4-UPM seems to be most protective. West Asia Organization for Cancer Prevention 2019 /pmc/articles/PMC6982671/ /pubmed/31653156 http://dx.doi.org/10.31557/APJCP.2019.20.10.3071 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Assayaghi, Rowa Mohammed
Alabsi, Aied Mohammed
Swethadri, Gumballi
Ali, Abdul Manaf
Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title_full Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title_fullStr Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title_full_unstemmed Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title_short Liver Pathology in Rats Treated with Newcastle Disease Virus Strains AF2240 and V4-UPM
title_sort liver pathology in rats treated with newcastle disease virus strains af2240 and v4-upm
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982671/
https://www.ncbi.nlm.nih.gov/pubmed/31653156
http://dx.doi.org/10.31557/APJCP.2019.20.10.3071
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