Detection of the Crystallization Process of Paracetamol with a Multi-Mode Optical Fiber in a Reflective Configuration

A configuration of a refractometer sensor is described with the aim of optically detecting the crystallization process of paracetamol. The developed sensing head is based on a conventional cleaved multi-mode fiber. The fiber tip sensor structure was submitted to contact with the liquid of interest (...

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Detalles Bibliográficos
Autores principales: Soares, Liliana, Novais, Susana, Ferreira, António, Frazão, Orlando, Silva, Susana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982736/
https://www.ncbi.nlm.nih.gov/pubmed/31877833
http://dx.doi.org/10.3390/s20010087
Descripción
Sumario:A configuration of a refractometer sensor is described with the aim of optically detecting the crystallization process of paracetamol. The developed sensing head is based on a conventional cleaved multi-mode fiber. The fiber tip sensor structure was submitted to contact with the liquid of interest (paracetamol fully dissolved in 40% v/v of ethanol/water) and the crystallization process of paracetamol, induced with continued exposure to air, was monitored in real time.

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