Lignans and Their Derivatives from Plants as Antivirals

Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activit...

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Detalles Bibliográficos
Autores principales: Cui, Qinghua, Du, Ruikun, Liu, Miaomiao, Rong, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982783/
https://www.ncbi.nlm.nih.gov/pubmed/31906391
http://dx.doi.org/10.3390/molecules25010183
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author Cui, Qinghua
Du, Ruikun
Liu, Miaomiao
Rong, Lijun
author_facet Cui, Qinghua
Du, Ruikun
Liu, Miaomiao
Rong, Lijun
author_sort Cui, Qinghua
collection PubMed
description Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed.
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spelling pubmed-69827832020-02-28 Lignans and Their Derivatives from Plants as Antivirals Cui, Qinghua Du, Ruikun Liu, Miaomiao Rong, Lijun Molecules Review Lignans are widely produced by various plant species; they are a class of natural products that share structural similarity. They usually contain a core scaffold that is formed by two or more phenylpropanoid units. Lignans possess diverse pharmacological properties, including their antiviral activities that have been reported in recent years. This review discusses the distribution of lignans in nature according to their structural classification, and it provides a comprehensive summary of their antiviral activities. Among them, two types of antiviral lignans—podophyllotoxin and bicyclol, which are used to treat venereal warts and chronic hepatitis B (CHB) in clinical, serve as examples of using lignans for antivirals—are discussed in some detail. Prospects of lignans in antiviral drug discovery are also discussed. MDPI 2020-01-01 /pmc/articles/PMC6982783/ /pubmed/31906391 http://dx.doi.org/10.3390/molecules25010183 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Cui, Qinghua
Du, Ruikun
Liu, Miaomiao
Rong, Lijun
Lignans and Their Derivatives from Plants as Antivirals
title Lignans and Their Derivatives from Plants as Antivirals
title_full Lignans and Their Derivatives from Plants as Antivirals
title_fullStr Lignans and Their Derivatives from Plants as Antivirals
title_full_unstemmed Lignans and Their Derivatives from Plants as Antivirals
title_short Lignans and Their Derivatives from Plants as Antivirals
title_sort lignans and their derivatives from plants as antivirals
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982783/
https://www.ncbi.nlm.nih.gov/pubmed/31906391
http://dx.doi.org/10.3390/molecules25010183
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AT duruikun lignansandtheirderivativesfromplantsasantivirals
AT liumiaomiao lignansandtheirderivativesfromplantsasantivirals
AT ronglijun lignansandtheirderivativesfromplantsasantivirals

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